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Details on Person miR-24 binds p16INK4A and p14ARF mRNAs

Class:Id	Reaction:3209151
_displayName	miR-24 binds p16INK4A and p14ARF mRNAs
_doRelease	TRUE
_timestamp	2019-11-01 05:06:33
authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3209135] Orlic-Milacic, M, 2013-03-01
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15 [InstanceEdit:9666043] Orlic-Milacic, Marija, 2019-11-01
input	[DefinedSet:3209130] p16INK4A/p14ARF mRNA [cytosol] [Homo sapiens] [Complex:3209134] miR-24 Nonendonucleolytic RISC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3209145] p16(INK4a) translation suppressed by miR-24 [LiteratureReference:3209136] Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development
modified	[InstanceEdit:3245958] Orlic-Milacic, M, 2013-03-28 [InstanceEdit:3779452] Orlic-Milacic, M, 2013-06-27 [InstanceEdit:3779453] Orlic-Milacic, M, 2013-06-27 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4420304] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4420306] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4542310] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:9645189] Orlic-Milacic, Marija, 2019-05-06 [InstanceEdit:9666047] Orlic-Milacic, Marija, 2019-11-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	miR-24 binds p16INK4A and p14ARF mRNAs
output	[Complex:3209131] p16INK4A/p14ARF mRNA: miR-24 Nonendonucleolytic RISC [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:3223200] Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription [Homo sapiens] [Reaction:3222593] KDM6B demethylates H3K27me3 on p16INK4A promoter [Homo sapiens] [BlackBoxEvent:3229138] MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription [Homo sapiens] [Reaction:3229102] p-MAPKAPK3 phosphorylates BMI1 [Homo sapiens] [BlackBoxEvent:3209109] E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA [Homo sapiens] [Reaction:3209096] E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter [Homo sapiens] [BlackBoxEvent:3209098] p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA [Homo sapiens] [Reaction:3200023] Phosphorylated ETS1 binds p16INK4A promoter [Homo sapiens] [Reaction:8979082] Phosphorylated ETS2 binds p16INK4A promoter [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03 [InstanceEdit:9666044] Vegi, Naidu M, 2019-10-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545093] R-HSA-3209151.4
summation	[Summation:3245946] MicroRNA miR-24 is able to bind both p16INK4A mRNA (Lal et a...
(hasEvent)	[Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens] [Pathway:2559585] Oncogene Induced Senescence [Homo sapiens] [Pathway:8853884] Transcriptional Regulation by VENTX [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:3209111] Translation of p14ARF mRNA is inhibited by miR-24 [Homo sapiens] [BlackBoxEvent:3209114] Translation of p16INK4A mRNA is inhibited by miR-24 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777822] Update Tracker - [Reaction:3209151] miR-24 binds p16INK4A and p14ARF mRNAs - v69:[modifyText]
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