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Details on Person MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin

Class:Id	Reaction:3149539
_displayName	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin
_doRelease	TRUE
_timestamp	2022-02-10 19:36:25
authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:3149542] methionine synthase activity of MTRR:MTR:cob(I)alamin [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3149501] Jassal, Bijay, 2013-02-15
edited	[InstanceEdit:3149501] Jassal, Bijay, 2013-02-15
input	[Complex:3149516] MTRR:MTR:cob(I)alamin [cytosol] [Homo sapiens] [SimpleEntity:200665] 5-methyl-THF [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:200732] Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders
modified	[InstanceEdit:3160770] Jassal, B, 2013-02-20 [InstanceEdit:3162930] Jassal, Bijay, 2013-02-21 [InstanceEdit:3288226] Jassal, Bijay, 2013-04-15 [InstanceEdit:3928680] Jassal, Bijay, 2013-07-23 [InstanceEdit:3968436] Jassal, Bijay, 2013-07-24 [InstanceEdit:9644853] Jassal, Bijay, 2019-04-25 [InstanceEdit:9759628] D'Eustachio, Peter, 2021-12-08 [InstanceEdit:9764259] D'Eustachio, Peter, 2022-02-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin
output	[Complex:3149551] MTRR:MTR:MeCbl [cytosol] [Homo sapiens] [SimpleEntity:111355] THF [cytosol]
precedingEvent	[Reaction:174374] MTR transfers CH3 from MeCbl to HCYS [Homo sapiens] [Reaction:200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG [Homo sapiens] [Reaction:200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG [Homo sapiens] [Reaction:174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Homo sapiens] [Reaction:3160769] MTR transfers CH3 from MTHFPG to B12s [Homo sapiens] [Reaction:3149518] MTRR reduces cob(II)alamin to meCbl [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654185] R-HSA-3149539.4
summation	[Summation:3968438] Methionine synthase (MTR) mediates the continuous shuttling ...
(hasEvent)	[Pathway:9759218] Cobalamin (Cbl) metabolism [Homo sapiens]
(normalReaction)	[FailedReaction:3321918] Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764871] Futile Cycle: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin
(updatedInstance)	[_UpdateTracker:9774919] Update Tracker - [Reaction:3149539] MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin - v80:[modifyText] [_UpdateTracker:9785944] Update Tracker - [Reaction:3149539] MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin - v50:[modifyText] [_UpdateTracker:9787027] Update Tracker - [Reaction:3149539] MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin - v46:[add_removeSummation]
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No pathways have been reviewed or authored by MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (3149539)