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Details on Person MMACHC decyanates CNCbl

Class:Id	Reaction:3149519
_displayName	MMACHC decyanates CNCbl
_doRelease	TRUE
_timestamp	2024-04-18 22:04:01
authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:3149491] cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity of MMACHC [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3149501] Jassal, Bijay, 2013-02-15
crossReference	[DatabaseIdentifier:9908088] RHEA:16115
edited	[InstanceEdit:3149501] Jassal, Bijay, 2013-02-15
input	[SimpleEntity:3149505] CNCbl [cytosol] [SimpleEntity:3149505] CNCbl [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [EntityWithAccessionedSequence:2980949] MMACHC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2980949] MMACHC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3149499] Decyanation of vitamin B12 by a trafficking chaperone [LiteratureReference:9759557] Structural basis of multifunctionality in a vitamin B12-processing enzyme [LiteratureReference:3245894] Vitamin B12: unique metalorganic compounds and the most complex vitamins
modified	[InstanceEdit:3162927] Jassal, Bijay, 2013-02-21 [InstanceEdit:3162930] Jassal, Bijay, 2013-02-21 [InstanceEdit:3245900] Jassal, Bijay, 2013-03-28 [InstanceEdit:3288226] Jassal, Bijay, 2013-04-15 [InstanceEdit:9758474] D'Eustachio, Peter, 2021-11-12 [InstanceEdit:9759436] D'Eustachio, Peter, 2021-12-03 [InstanceEdit:9759552] D'Eustachio, Peter, 2021-12-06 [InstanceEdit:9760391] D'Eustachio, Peter, 2021-12-17 [InstanceEdit:9764259] D'Eustachio, Peter, 2022-02-10 [InstanceEdit:9764875] D'Eustachio, Peter, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9908099] D'Eustachio, Peter, 2024-04-18
name	MMACHC decyanates CNCbl MMACHC reductively decyanates CNCbl 2 apo--(cyanocobalamin reductase) + 2 cyanocob(III)alamin + H(+) + NADPH => 2 cob(II)alamin--(cyanocobalamin reductase) + 2 hydrogen cyanide + NADP(+)
negativePrecedingEvent	[NegativePrecedingEvent:9764879] Incorrect Order: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria [NegativePrecedingEvent:9764874] Incorrect Order: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR
output	[Complex:3095903] MMACHC:cob(II)alamin [cytosol] [Homo sapiens] [Complex:3095903] MMACHC:cob(II)alamin [cytosol] [Homo sapiens] [SimpleEntity:1130611] HCN [cytosol] [SimpleEntity:1130611] HCN [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:9759206] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol [Homo sapiens] [BlackBoxEvent:3000263] TCN2:RCbl is degraded to release RCbl [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654295] R-HSA-3149519.5
summation	[Summation:3149511] Cyanocobalamin (CNCbl), a semisynthetic molecule produced fr...
(hasEvent)	[Pathway:9759218] Cobalamin (Cbl) metabolism [Homo sapiens]
(normalReaction)	[FailedReaction:3318590] Defective MMACHC does not decyanate CNCbl [Homo sapiens]
(precedingEvent)	[Reaction:3149494] MMACHC:cob(II)alamin binds MMADHC [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774984] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v80:[addLiteratureReference, modifyText] [_UpdateTracker:9786303] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v50:[modifyText] [_UpdateTracker:9787110] Update Tracker - [Reaction:3149519] MMACHC decyanates CNCbl - v46:[modifyText]
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No pathways have been reviewed or authored by MMACHC decyanates CNCbl (3149519)