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Details on Person MMACHC:cob(II)alamin binds MMADHC

Class:Id	Reaction:3149494
_displayName	MMACHC:cob(II)alamin binds MMADHC
_doRelease	TRUE
_timestamp	2024-07-19 18:51:05
authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:9908090] molecular carrier activity of MMADHC [cytosol]
catalystActivityReference	[CatalystActivityReference:9908095] molecular carrier activity of MMADHC [cytosol] Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B?? metabolism
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3149501] Jassal, Bijay, 2013-02-15
edited	[InstanceEdit:3149501] Jassal, Bijay, 2013-02-15
input	[Complex:3095903] MMACHC:cob(II)alamin [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3149529] MMADHC [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9908944] D'Eustachio, Peter, 2024-04-24
isChimeric	FALSE
literatureReference	[LiteratureReference:9758714] Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking [LiteratureReference:3149525] Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism [LiteratureReference:3149487] Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B?? metabolism [LiteratureReference:3149523] Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism [LiteratureReference:3149550] Gene identification for the cblD defect of vitamin B12 metabolism
modified	[InstanceEdit:3162930] Jassal, Bijay, 2013-02-21 [InstanceEdit:3288226] Jassal, Bijay, 2013-04-15 [InstanceEdit:3928680] Jassal, Bijay, 2013-07-23 [InstanceEdit:9759552] D'Eustachio, Peter, 2021-12-06 [InstanceEdit:9759585] D'Eustachio, Peter, 2021-12-07 [InstanceEdit:9764259] D'Eustachio, Peter, 2022-02-10 [InstanceEdit:9764875] D'Eustachio, Peter, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9908099] D'Eustachio, Peter, 2024-04-18 [InstanceEdit:9908943] D'Eustachio, Peter, 2024-04-24 [InstanceEdit:9916040] D'Eustachio, Peter, 2024-07-19
name	MMACHC:cob(II)alamin binds MMADHC
negativePrecedingEvent	[NegativePrecedingEvent:9764887] Incorrect Order: MMADHC targets transport of cytosolic cob(II)alamin to mitochondria [NegativePrecedingEvent:9764877] Incorrect Order: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR
output	[Complex:3149533] MMACHC:MMADHC:cob(II)alamin [cytosol] [Homo sapiens]
precedingEvent	[Reaction:3149519] MMACHC decyanates CNCbl [Homo sapiens] [Reaction:9759206] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol [Homo sapiens] [BlackBoxEvent:9759549] Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin [Homo sapiens] [Reaction:3095889] MMACHC dealkylates RCbl [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2013-06-11
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15 [InstanceEdit:9916041] Hill, David P, 2024-07-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654328] R-HSA-3149494.5
structureModified	[InstanceEdit:9908099] D'Eustachio, Peter, 2024-04-18
summation	[Summation:3149490] MMACHC (Methylmalonic aciduria and homocystinuria type C pro...
(hasEvent)	[Pathway:9759218] Cobalamin (Cbl) metabolism [Homo sapiens]
(normalReaction)	[FailedReaction:3318571] Defective MMADHC does not bind MMACHC:B12r [Homo sapiens]
(precedingEvent)	[Reaction:3149563] MMADHC targets transport of cytosolic cob(II)alamin to mitochondria [Homo sapiens] [BlackBoxEvent:3204318] cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775060] Update Tracker - [Reaction:3149494] MMACHC:cob(II)alamin binds MMADHC - v80:[addLiteratureReference, modifyText] [_UpdateTracker:9785962] Update Tracker - [Reaction:3149494] MMACHC:cob(II)alamin binds MMADHC - v50:[modifyText] [_UpdateTracker:9787062] Update Tracker - [Reaction:3149494] MMACHC:cob(II)alamin binds MMADHC - v46:[modifyText] [_UpdateTracker:9911024] Update Tracker - [Reaction:3149494] MMACHC:cob(II)alamin binds MMADHC - v89:[addCatalystActivity]
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No pathways have been reviewed or authored by MMACHC:cob(II)alamin binds MMADHC (3149494)