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Details on Person STING ubiquitination by TRIM32 or TRIM56

Class:Id	Reaction:3134804
_displayName	STING ubiquitination by TRIM32 or TRIM56
_doRelease	TRUE
_timestamp	2013-05-31 09:40:32
authored	[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
catalystActivity	[CatalystActivity:3134802] ubiquitin-protein transferase activity of STING:TRIM32/TRIM56 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:3134801] Shamovsky, V, 2013-02-13
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
input	[Complex:1834963] STING:TRIM32/TRIM56 [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1964498] The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA [LiteratureReference:3244658] TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination
modified	[InstanceEdit:3134978] Shamovsky, V, 2013-02-13 [InstanceEdit:3244664] Shamovsky, V, 2013-03-28 [InstanceEdit:3248025] Shamovsky, V, 2013-04-05 [InstanceEdit:3249352] Shamovsky, V, 2013-04-08 [InstanceEdit:3249401] Shamovsky, V, 2013-04-09 [InstanceEdit:3465584] Shamovsky, V, 2013-05-17 [InstanceEdit:3465600] Shamovsky, V, 2013-05-17 [InstanceEdit:3465604] Shamovsky, V, 2013-05-17 [InstanceEdit:3597629] Shamovsky, V, 2013-05-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STING ubiquitination by TRIM32 or TRIM56
output	[DefinedSet:3244609] TRIM32/TRIM56 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3134805] K63polyUb-STING [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:1964496] STING binds TRIM32 or TRIM56 [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654293] R-HSA-3134804.2
summation	[Summation:3249350] E3 ubiquitin-protein ligase TRIM32 and TRIM56 were shown to ...
(hasEvent)	[Pathway:3134975] Regulation of innate immune responses to cytosolic DNA [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764712] Incorrect Order: STING ubiquitination by TRIM32 or TRIM56 [Reaction:3134800] STING dimerization [Homo sapiens]
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No pathways have been reviewed or authored by STING ubiquitination by TRIM32 or TRIM56 (3134804)