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Details on Person Cobalamins in a +3 oxidation state and with various R groups...
| Class:Id | Summation:3132774 |
|---|---|
| _displayName | Cobalamins in a +3 oxidation state and with various R groups... |
| _timestamp | 2023-05-25 22:56:02 |
| created | [InstanceEdit:3132777] Jassal, Bijay, 2013-02-13 |
| modified | [InstanceEdit:3149501] Jassal, Bijay, 2013-02-15 [InstanceEdit:3245900] Jassal, Bijay, 2013-03-28 [InstanceEdit:5621564] Jassal, Bijay, 2014-09-01 [InstanceEdit:5621619] Jassal, Bijay, 2014-09-01 [InstanceEdit:9758882] D'Eustachio, Peter, 2021-11-26 [InstanceEdit:9759391] D'Eustachio, Peter, 2021-12-02 [InstanceEdit:9836318] D'Eustachio, Peter, 2023-05-25 |
| text | Cobalamins in a +3 oxidation state and with various R groups (collectively, RCbl) are present in the diet as free molecules or complexed with dietary protein. The glycoprotein transcobalamin 1 (TCN1 aka haptocorrin, HC, TCII), produced by salivary glands (Morkbak et al. 2007, Wang et al. 2019), binds free RCbl and in the stomach binds RCbl freed by the initial digestion of dietary protein. In its complexed form acid-sensitive RCbl is protected from degradation in the stomach (Nielsen et al. 2012) and is available for endocytosis. |
| (summation) | [Reaction:3132759] TCN1 binds RCbl [Homo sapiens] |
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No pathways have been reviewed or authored by Cobalamins in a +3 oxidation state and with various R groups... (3132774)
