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Details on Person MAPKs phosphorylate ETS1 and ETS2

Class:Id	Reaction:3132737
_displayName	MAPKs phosphorylate ETS1 and ETS2
_doRelease	TRUE
_timestamp	2017-02-21 18:09:14
authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:198713] protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3132723] Orlic-Milacic, M, 2013-02-12
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
input	[DefinedSet:3132719] ETS1/ETS2 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3132729] Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 [LiteratureReference:3132718] An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors [LiteratureReference:3166783] Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment [LiteratureReference:3166776] Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP [LiteratureReference:3199775] p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter
modified	[InstanceEdit:3166780] Orlic-Milacic, M, 2013-02-22 [InstanceEdit:3199778] Orlic-Milacic, M, 2013-02-27 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4420304] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4420306] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4542310] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:8979089] Orlic-Milacic, Marija, 2017-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAPKs phosphorylate ETS1 and ETS2
output	[DefinedSet:3132724] p-T38-ETS1/ p-T72-ETS2 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens] [Reaction:5672980] Dissociation of RAS:RAF complex [Homo sapiens] [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 [Homo sapiens] [BlackBoxEvent:109863] Dissociation of p-T,Y-MAPK3:MAP2K1 [Homo sapiens] [BlackBoxEvent:9610154] Dissociation of phosphorylated MAP2Ks and MAPKs [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545029] R-HSA-3132737.3
summation	[Summation:3166778] Both ETS1 and ETS2 contain a consensus site (PLLTP) for MAPK...
(hasEvent)	[Pathway:2559585] Oncogene Induced Senescence [Homo sapiens]
(precedingEvent)	[Reaction:3200023] Phosphorylated ETS1 binds p16INK4A promoter [Homo sapiens] [Reaction:3209165] ID1 sequesters ETS2 [Homo sapiens] [Reaction:8979082] Phosphorylated ETS2 binds p16INK4A promoter [Homo sapiens] [Reaction:9942107] ETS-1 binding to CD6 gene [Homo sapiens]
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No pathways have been reviewed or authored by MAPKs phosphorylate ETS1 and ETS2 (3132737)