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Details on Person SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1

Class:Id	Reaction:3108212
_displayName	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1
_doRelease	TRUE
_timestamp	2019-04-07 13:51:00
authored	[InstanceEdit:3065680] May, B, 2013-02-06
catalystActivity	[CatalystActivity:3108233] SUMO transferase activity of SMC5-SMC6 Complex [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644110] SUMO transferase activity of SMC5-SMC6 Complex [nucleoplasm] Human MMS21/NSE2 is a SUMO ligase required for DNA repair
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3108223] May, B, 2013-02-10
edited	[InstanceEdit:3065680] May, B, 2013-02-06
input	[Complex:1641505] Cohesin Complex [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3108229] Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl [LiteratureReference:3108181] Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks [LiteratureReference:5215899] The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability
modified	[InstanceEdit:3826675] May, B, 2013-07-08 [InstanceEdit:4663810] May, B, 2013-10-06 [InstanceEdit:5228347] May, B, 2014-01-10 [InstanceEdit:5677004] May, Bruce, 2015-02-21 [InstanceEdit:9644111] May, Bruce, 2019-04-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1
output	[Complex:3108231] SUMOylated Cohesin [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679709] R-HSA-3108212.3
summation	[Summation:4663783] The NSMCE2 (NSE2, MMS21) subunit of the SMC5/6 complex SUMOy...
(hasEvent)	[Pathway:3108214] SUMOylation of DNA damage response and repair proteins [Homo sapiens]
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No pathways have been reviewed or authored by SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (3108212)