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Details on Person Myosin phosphatase dephosphorylates PLK1

Class:IdReaction:3002811
_displayNameMyosin phosphatase dephosphorylates PLK1
_doReleaseTRUE
_timestamp2022-02-08 21:54:30
authored[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
catalystActivity[CatalystActivity:3002817] protein serine/threonine phosphatase activity of Phosphorylated Myosin Phosphatase [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:3002813] Orlic-Milacic, M, 2013-01-28
edited[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29
input[EntityWithAccessionedSequence:3002800] p-T210-PLK1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113518] H2O [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:3002815] Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
[LiteratureReference:2562529] Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression
[LiteratureReference:3004742] LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression
modified[InstanceEdit:3002853] Orlic-Milacic, M, 2013-01-28
[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
[InstanceEdit:3004745] Orlic-Milacic, M, 2013-01-29
[InstanceEdit:3006235] Orlic-Milacic, M, 2013-01-29
[InstanceEdit:3110288] Orlic-Milacic, M, 2013-02-11
[InstanceEdit:8933141] Orlic-Milacic, Marija, 2016-08-03
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9764039] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764050] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameMyosin phosphatase dephosphorylates PLK1
negativePrecedingEvent[NegativePrecedingEvent:9764030] Futile Cycle: PLK1 phosphorylates FOXM1
output[EntityWithAccessionedSequence:156720] PLK1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113550] Pi [nucleoplasm]
precedingEvent
regulatedBy[PositiveRegulation:3004729] Positive regulation by 'p-S177-OPTN [nucleoplasm]'
regulationReference[RegulationReference:9641391] Positive regulation by 'p-S177-OPTN [nucleoplasm]' Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression
releaseDate2013-03-12
reviewed[InstanceEdit:3110287] Weil, Robert, 2013-02-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200309] R-HSA-3002811.6
summation[Summation:3002835] The myosin phosphatase complex can dephosphorylate PLK1 thre...
(hasEvent)[Pathway:2565942] Regulation of PLK1 Activity at G2/M Transition [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787032] Update Tracker - [Reaction:3002811] Myosin phosphatase dephosphorylates PLK1 - v46:[modifyText]
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No pathways have been reviewed or authored by Myosin phosphatase dephosphorylates PLK1 (3002811)
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