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Details on Person UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2

Class:Id	Reaction:3000449
_displayName	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2
_doRelease	TRUE
_timestamp	2020-02-12 19:49:27
authored	[InstanceEdit:9667932] Gerace, Larry, 2019-11-07
catalystActivity	[CatalystActivity:2997650] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9644118] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm] Identification of a substrate recognition site on Ubc9
compartment	[Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm
created	[InstanceEdit:3000365] May, B, 2013-01-26
edited	[InstanceEdit:2997736] May, B, 2013-01-23 [InstanceEdit:9668537] Orlic-Milacic, Marija, 2019-11-26
input	[Complex:9626018] RANGAP1 homodimer [nuclear envelope] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3000444] Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue [LiteratureReference:4085361] Ubc9 sumoylation regulates SUMO target discrimination [LiteratureReference:9668318] A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
modified	[InstanceEdit:3065680] May, B, 2013-02-06 [InstanceEdit:3730900] May, B, 2013-06-16 [InstanceEdit:3899313] May, B, 2013-07-12 [InstanceEdit:5626886] May, Bruce, 2014-10-11 [InstanceEdit:5655646] May, Bruce, 2014-12-08 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9626020] Orlic-Milacic, Marija, 2018-10-24 [InstanceEdit:9644119] May, Bruce, 2019-04-08 [InstanceEdit:9645037] Orlic-Milacic, Marija, 2019-05-02 [InstanceEdit:9645372] Orlic-Milacic, Marija, 2019-05-10 [InstanceEdit:9667982] Orlic-Milacic, Marija, 2019-11-18 [InstanceEdit:9668322] Orlic-Milacic, Marija, 2019-11-25 [InstanceEdit:9668545] Orlic-Milacic, Marija, 2019-11-27 [InstanceEdit:9668551] Orlic-Milacic, Marija, 2019-11-27 [InstanceEdit:9676327] Orlic-Milacic, Marija, 2020-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 Conjugation of SUMO1 to RANGAP1
output	[Complex:9624892] SUMO1:RANGAP1 homodimer [nuclear envelope] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8917302] R-HSA-3000449.2
summation	[Summation:3899281] The majority of RANGAP1 in the cell is conjugated with SUMO1...
(hasEvent)	[Pathway:9615933] Postmitotic nuclear pore complex (NPC) reformation [Homo sapiens] [Pathway:9793242] SUMOylation of nuclear envelope proteins [Homo sapiens]
(precedingEvent)	[Reaction:9624893] RAN stimulates fusion of nuclear envelope (NE) membranes [Homo sapiens]
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No pathways have been reviewed or authored by UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (3000449)