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Details on Person RANBP2 SUMOylates PML with SUMO2
Class:Id Reaction:3000411
_displayName RANBP2 SUMOylates PML with SUMO2
_doRelease TRUE
_timestamp 2019-04-08 08:03:39
authored [InstanceEdit:2997736] May, B, 2013-01-23
catalystActivity [CatalystActivity:3000418] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
catalystActivityReference [CatalystActivityReference:9644133] SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
compartment [Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created [InstanceEdit:3000365] May, B, 2013-01-26
edited [InstanceEdit:2997736] May, B, 2013-01-23
input [EntityWithAccessionedSequence:1031706] PML [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens] [Complex:2993778] SUMO2:UBE2I [nucleoplasm] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:3000394] Covalent modification of PML by the sentrin family of ubiquitin-like proteins [LiteratureReference:3000459] Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection [LiteratureReference:3000428] A proteomic study of SUMO-2 target proteins [LiteratureReference:5627513] Proteome-wide identification of SUMO2 modification sites
modified [InstanceEdit:3065680] May, B, 2013-02-06 [InstanceEdit:3730795] May, B, 2013-06-15 [InstanceEdit:4663810] May, B, 2013-10-06 [InstanceEdit:5627522] May, Bruce, 2014-10-19 [InstanceEdit:5677004] May, Bruce, 2015-02-21 [InstanceEdit:9644134] May, Bruce, 2019-04-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name RANBP2 SUMOylates PML with SUMO2 Conjugation of SUMO2 to PML
output [EntityWithAccessionedSequence:3000423] polySUMO2-K65,K160,K490-PML [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate 2015-03-19
reviewed [InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:5680128] R-HSA-3000411.3
summation [Summation:4663767] RANBP2 of the nuclear pore complex SUMOylates PML with SUMO2...
(hasEvent) [Pathway:3108214] SUMOylation of DNA damage response and repair proteins [Homo sapiens]
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