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Details on Person SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA

Class:Id	Reaction:3000335
_displayName	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
_doRelease	TRUE
_timestamp	2022-02-08 21:54:40
authored	[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
catalystActivity	[CatalystActivity:3000336] ubiquitin-protein transferase activity of p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3000338] Orlic-Milacic, M, 2013-01-24
edited	[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29
input	[Complex:3000340] p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3000332] Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
modified	[InstanceEdit:3002853] Orlic-Milacic, M, 2013-01-28 [InstanceEdit:4410469] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410475] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410476] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4410477] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:9764023] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9764050] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
negativePrecedingEvent	[NegativePrecedingEvent:9764019] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53 [NegativePrecedingEvent:9764046] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [NegativePrecedingEvent:9764049] Futile Cycle: Proteasome-mediated degradation of PolyUb-FBXL7
output	[Complex:3000337] Ub-p-8S,3T-BORA [cytosol] [Homo sapiens] [DefinedSet:1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 [Homo sapiens] [Reaction:3000327] PLK1 phosphorylates BORA [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545115] R-HSA-3000335.3
summation	[Summation:3002840] SCF-beta-TrCP ubiquitin ligases promote ubiquitination and d...
(hasEvent)	[Pathway:2565942] Regulation of PLK1 Activity at G2/M Transition [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764054] Futile Cycle: SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
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