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Details on Person Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

Class:IdLiteratureReference:3000332
_displayNamePlk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
_timestamp2013-01-24 20:49:59
author[Person:3000306] Seki, Akiko
[Person:3000311] Coppinger, Judith A
[Person:3000331] Du, Haining
[Person:3000309] Jang, Chang-Young
[Person:3000308] Yates, John R
[Person:3000314] Fang, Guowei
created[InstanceEdit:3000329] Orlic-Milacic, M, 2013-01-24
journalJ. Cell Biol.
pages65-78
pubMedIdentifier18378770
titlePlk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
volume181
year2008
(literatureReference)[Pathway:2565942] Regulation of PLK1 Activity at G2/M Transition [Homo sapiens]
[Reaction:3000327] PLK1 phosphorylates BORA [Homo sapiens]
[Reaction:3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA [Homo sapiens]
[Reaction:3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 [Homo sapiens]
[CatalystActivityReference:9643264] protein serine/threonine kinase activity of p-S252-BORA:p-T210-PLK1 [cytosol] Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
[Complex:3000340] p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] [Homo sapiens]
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