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Details on Person PLK1 phosphorylates BORA

Class:IdReaction:3000327
_displayNamePLK1 phosphorylates BORA
_doReleaseTRUE
_timestamp2013-09-05 11:44:50
authored[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
catalystActivity[CatalystActivity:3000326] protein serine/threonine kinase activity of p-7S,2T-BORA:p-T210-PLK1 [cytosol]
catalystActivityReference[CatalystActivityReference:9643264] protein serine/threonine kinase activity of p-S252-BORA:p-T210-PLK1 [cytosol] Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
compartment[Compartment:70101] cytosol
created[InstanceEdit:3000329] Orlic-Milacic, M, 2013-01-24
edited[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29
input[Complex:3000305] p-7S,2T-BORA:p-T210-PLK1 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:3000332] Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
modified[InstanceEdit:3002853] Orlic-Milacic, M, 2013-01-28
[InstanceEdit:4410469] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410475] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410476] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410477] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePLK1 phosphorylates BORA
output[EntityWithAccessionedSequence:3000318] p-T210-PLK1 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[EntityWithAccessionedSequence:3000330] p-8S,3T-BORA [cytosol] [Homo sapiens]
precedingEvent
releaseDate2013-09-18
reviewed[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545168] R-HSA-3000327.3
summation[Summation:3002842] PLK1 phosphorylates BORA on serine residue S497 and threonin...
(hasEvent)[Pathway:2565942] Regulation of PLK1 Activity at G2/M Transition [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9764024] Futile Cycle: PLK1 phosphorylates BORA
[NegativePrecedingEvent:9764028] Futile Cycle: PLK1 phosphorylates BORA
[NegativePrecedingEvent:9764029] Futile Cycle: PLK1 phosphorylates BORA
[NegativePrecedingEvent:9764034] Futile Cycle: PLK1 phosphorylates BORA
[Reaction:156682] PLK1 phosphorylates NUDC [Homo sapiens]
[Reaction:1638803] Phosphorylation of cohesin by PLK1 at centromeres [Homo sapiens]
[Reaction:2172194] Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) [Homo sapiens]
[Reaction:2466068] Phosphorylation of cohesin by PLK1 at chromosomal arms [Homo sapiens]
[Reaction:2984226] PLK1 phosphorylates NEK9 [Homo sapiens]
[Reaction:3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 [Homo sapiens]
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