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Query author contributions in Reactome

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Details on Person BORA binds PLK1 and AURKA

Class:IdReaction:3000319
_displayNameBORA binds PLK1 and AURKA
_doReleaseTRUE
_timestamp2025-01-22 15:36:03
authored[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
compartment[Compartment:70101] cytosol
created[InstanceEdit:3000317] Orlic-Milacic, M, 2013-01-24
edited[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29
[InstanceEdit:9929534] Orlic-Milacic, Marija, 2024-11-26
input[Complex:3000302] Centrosome:p-T288-AURKA [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:164603] PLK1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:4086411] p-7S,2T-BORA [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3000320] Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
[LiteratureReference:2565943] Mitotic activation of the kinase Aurora-A requires its binding partner Bora
modified[InstanceEdit:3002802] Orlic-Milacic, M, 2013-01-28
[InstanceEdit:3002853] Orlic-Milacic, M, 2013-01-28
[InstanceEdit:4086414] Orlic-Milacic, M, 2013-08-08
[InstanceEdit:4410469] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410475] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410476] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4410477] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:8933142] Orlic-Milacic, Marija, 2016-08-03
[InstanceEdit:8953417] Orlic-Milacic, Marija, 2016-12-22
[InstanceEdit:9764017] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929539] Orlic-Milacic, Marija, 2024-11-26
[InstanceEdit:9932263] Orlic-Milacic, Marija, 2024-12-18
[InstanceEdit:9936322] Orlic-Milacic, Marija, 2025-01-22
nameBORA binds PLK1 and AURKA
negativePrecedingEvent[NegativePrecedingEvent:9764016] Futile Cycle: AURKA phosphorylates PLK1
output[Complex:3000313] Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2013-09-18
reviewed[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21
[InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545214] R-HSA-3000319.6
summation[Summation:3002850] BORA is able to interact with both AURKA (Aurora A kinase) a...
(hasEvent)[Pathway:2565942] Regulation of PLK1 Activity at G2/M Transition [Homo sapiens]
(precedingEvent)[Reaction:3000310] AURKA phosphorylates PLK1 [Homo sapiens]
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