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Details on Person TCN2:RCbl is degraded to release RCbl

Class:Id	BlackBoxEvent:3000263
_displayName	TCN2:RCbl is degraded to release RCbl
_doRelease	TRUE
_timestamp	2022-02-14 15:47:13
authored	[InstanceEdit:3000234] Jassal, Bijay, 2013-01-24
catalystActivity	[CatalystActivity:8960084] peptidase activity of unknown protease [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:3000234] Jassal, Bijay, 2013-01-24
edited	[InstanceEdit:3000234] Jassal, Bijay, 2013-01-24
input	[Complex:3000242] TCN2:RCbl [lysosomal lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3000097] Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts
modified	[InstanceEdit:3095883] Jassal, Bijay, 2013-02-08 [InstanceEdit:3132777] Jassal, Bijay, 2013-02-13 [InstanceEdit:3162927] Jassal, Bijay, 2013-02-21 [InstanceEdit:3162930] Jassal, Bijay, 2013-02-21 [InstanceEdit:3165246] Jassal, B, 2013-02-22 [InstanceEdit:3288226] Jassal, Bijay, 2013-04-15 [InstanceEdit:3968436] Jassal, Bijay, 2013-07-24 [InstanceEdit:9658200] D'Eustachio, Peter, 2019-08-12 [InstanceEdit:9758898] D'Eustachio, Peter, 2021-11-26 [InstanceEdit:9759431] D'Eustachio, Peter, 2021-12-03 [InstanceEdit:9764875] D'Eustachio, Peter, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TCN2:RCbl is degraded to release RCbl
output	[SimpleEntity:9759390] RCbl [lysosomal lumen]
precedingEvent	[BlackBoxEvent:3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome [Homo sapiens] [Reaction:3000122] CD320 binds extracellular TCN2:RCbl [Homo sapiens] [BlackBoxEvent:9759202] LRP2-mediated TCN2:RCbl uptake and delivery to lysosome [Homo sapiens] [Reaction:9759209] LRP2 binds extracellular TCN2:RCbl [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654200] R-HSA-3000263.4
summation	[Summation:3000297] A lysosomal protease that is sensitive to treatment with chl...
(hasEvent)	[Pathway:9758890] Transport of RCbl within the body [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764883] Different Cell Type: TCN2:RCbl is degraded to release RCbl [Reaction:9759206] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774863] Update Tracker - [BlackBoxEvent:3000263] TCN2:RCbl is degraded to release RCbl - v80:[addCatalystActivity, add_removeOutput, modifyText, removeLiteratureReference] [_UpdateTracker:9777615] Update Tracker - [BlackBoxEvent:3000263] TCN2:RCbl is degraded to release RCbl - v70:[removeOutput] [_UpdateTracker:9787166] Update Tracker - [BlackBoxEvent:3000263] TCN2:RCbl is degraded to release RCbl - v46:[modifyText]
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