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Details on Person Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl

Class:Id	BlackBoxEvent:3000243
_displayName	Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl
_doRelease	TRUE
_timestamp	2021-12-03 20:07:02
authored	[InstanceEdit:3000234] Jassal, Bijay, 2013-01-24
catalystActivity	[CatalystActivity:8960084] peptidase activity of unknown protease [lysosomal lumen]
catalystActivityReference	[CatalystActivityReference:9759430] peptidase activity of unknown protease [lysosomal lumen] The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:3000234] Jassal, Bijay, 2013-01-24
edited	[InstanceEdit:3000234] Jassal, Bijay, 2013-01-24
input	[Complex:3000280] CBLIF:RCbl [lysosomal lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3000149] The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless
modified	[InstanceEdit:3162927] Jassal, Bijay, 2013-02-21 [InstanceEdit:3162930] Jassal, Bijay, 2013-02-21 [InstanceEdit:3288226] Jassal, Bijay, 2013-04-15 [InstanceEdit:8960085] Jassal, Bijay, 2017-02-02 [InstanceEdit:9749834] Jassal, Bijay, 2021-08-06 [InstanceEdit:9758887] D'Eustachio, Peter, 2021-11-26 [InstanceEdit:9759431] D'Eustachio, Peter, 2021-12-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl
output	[SimpleEntity:9759390] RCbl [lysosomal lumen]
precedingEvent	[BlackBoxEvent:3000137] CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome [Homo sapiens] [Reaction:3000103] CUBN:AMN binds CBLIF:RCbl [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654390] R-HSA-3000243.5
summation	[Summation:3162931] A lysosomal protease that is inhibited by leupeptin and sens...
(hasEvent)	[Pathway:9758881] Uptake of dietary cobalamins into enterocytes [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764892] Different Cell Type: Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl [Reaction:5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775147] Update Tracker - [BlackBoxEvent:3000243] Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl - v80:[add_removeOutput, modifyText] [_UpdateTracker:9775822] Update Tracker - [BlackBoxEvent:3000243] Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl - v78:[modifyText] [_UpdateTracker:9782013] Update Tracker - [BlackBoxEvent:3000243] Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl - v60:[addCatalystActivity, modifyText]
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