Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person In the mucosal cells of the distal ileum, in preparation for...
| Class:Id | Summation:3000154 |
|---|---|
| _displayName | In the mucosal cells of the distal ileum, in preparation for... |
| _timestamp | 2022-01-27 22:33:47 |
| created | [InstanceEdit:3000139] Jassal, Bijay, 2013-01-24 |
| modified | [InstanceEdit:3000234] Jassal, Bijay, 2013-01-24 [InstanceEdit:3095883] Jassal, Bijay, 2013-02-08 [InstanceEdit:3245900] Jassal, Bijay, 2013-03-28 [InstanceEdit:5621564] Jassal, Bijay, 2014-09-01 [InstanceEdit:9749834] Jassal, Bijay, 2021-08-06 [InstanceEdit:9758882] D'Eustachio, Peter, 2021-11-26 [InstanceEdit:9759391] D'Eustachio, Peter, 2021-12-02 [InstanceEdit:9762781] D'Eustachio, Peter, 2022-01-27 |
| text | In the mucosal cells of the distal ileum, in preparation for internalisation, the gastric intrinsic factor:cobalamin (CBLIF:RCbl) complex interacts with cubilin (CUBN). CUBN is a cotransporter facilitating uptake of lipoproteins, vitamins and iron (Matthews et al. 2007). A CUBN trimer forms a complex with amnionless (AMN) protein, a necessary component which directs subcellular localization and endocytosis of CBLIF:RCbl (Fyfe et al. 2004, Larsen et al. 2018, Anderson et al. 2010). Defects in CUBN and AMN both cause recessive hereditary megaloblastic anemia 1 (RH MGA1 aka MGA1 Norwegian type or Imerslund Grasbeck syndrome, I GS; MIM:261100). The resultant malabsorption of RCbl leads to failure of the two reactions that require RCbl-derived cofactors (Aminoff et al. 1999, Kristiansen et al. 2000, Tanner et al. 2003, Densupsoontorn et al. 2012). |
| (summation) | [Reaction:3000103] CUBN:AMN binds CBLIF:RCbl [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by In the mucosal cells of the distal ileum, in preparation for... (3000154)
