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Details on Person PIAS1,4 SUMOylates BRCA1 with SUMO1

Class:Id	Reaction:2997709
_displayName	PIAS1,4 SUMOylates BRCA1 with SUMO1
_doRelease	TRUE
_timestamp	2022-01-19 16:40:41
authored	[InstanceEdit:2993796] May, B, 2013-01-19
catalystActivity	[CatalystActivity:2997675] SUMO transferase activity of PIAS1,4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2997618] May, B, 2013-01-23
edited	[InstanceEdit:2993796] May, B, 2013-01-19
input	[EntityWithAccessionedSequence:50949] BRCA1 [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2997575] The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress [LiteratureReference:2997611] A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells [LiteratureReference:2997586] Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
modified	[InstanceEdit:3006236] May, B, 2013-01-29 [InstanceEdit:3065680] May, B, 2013-02-06 [InstanceEdit:3730756] May, B, 2013-06-15 [InstanceEdit:5677004] May, Bruce, 2015-02-21 [InstanceEdit:9762281] May, Bruce, 2022-01-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIAS1,4 SUMOylates BRCA1 with SUMO1 Conjugation of SUMO1 to BRCA1
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2997644] monoSUMO1-K109-BRCA1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5680248] R-HSA-2997709.3
summation	[Summation:2997720] PIAS1,4 SUMOylate BRCA1 with SUMO1 at lysine-109 (Morris et ...
(hasEvent)	[Pathway:3108214] SUMOylation of DNA damage response and repair proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775006] Update Tracker - [Reaction:2997709] PIAS1,4 SUMOylates BRCA1 with SUMO1 - v80:[add_removeOutput]
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No pathways have been reviewed or authored by PIAS1,4 SUMOylates BRCA1 with SUMO1 (2997709)