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Details on Person MDM2 SUMOylates TP53 with SUMO2,3

Class:Id	Reaction:2997706
_displayName	MDM2 SUMOylates TP53 with SUMO2,3
_doRelease	TRUE
_timestamp	2022-01-18 18:46:16
authored	[InstanceEdit:2993796] May, B, 2013-01-19
catalystActivity	[CatalystActivity:2997569] SUMO transferase activity of p14-ARF:MDM2 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643980] SUMO transferase activity of p14-ARF:MDM2 [nucleoplasm] MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2997618] May, B, 2013-01-23
edited	[InstanceEdit:2993796] May, B, 2013-01-19
input	[EntityWithAccessionedSequence:69488] TP53 [nucleoplasm] [Homo sapiens] [DefinedSet:3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] [Homo sapiens] [DefinedSet:3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2997634] MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity [LiteratureReference:5626896] Uncovering global SUMOylation signaling networks in a site-specific manner [LiteratureReference:5627513] Proteome-wide identification of SUMO2 modification sites
modified	[InstanceEdit:3065680] May, B, 2013-02-06 [InstanceEdit:3730661] May, B, 2013-06-14 [InstanceEdit:3899313] May, B, 2013-07-12 [InstanceEdit:4663810] May, B, 2013-10-06 [InstanceEdit:5626908] May, Bruce, 2014-10-13 [InstanceEdit:5627522] May, Bruce, 2014-10-19 [InstanceEdit:8851595] May, Bruce, 2016-01-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9762188] May, Bruce, 2022-01-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MDM2 SUMOylates TP53 with SUMO2,3 Conjugation of SUMO2,3 to TP53
output	[EntityWithAccessionedSequence:2997661] polySUMO2,3-K386-TP53 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2993784] Conjugation of SUMO2 to UBA2:SAE1 [Homo sapiens] [Reaction:2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2993781] Conjugation of SUMO3 to UBA2:SAE1 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8851593] Vousden, Karen H, 2016-01-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861373] R-HSA-2997706.4
summation	[Summation:4663736] MDM2 in a complex with CDKN2A (p14-ARF) SUMOylates TP53 (p53...
(hasEvent)	[Pathway:3232118] SUMOylation of transcription factors [Homo sapiens]
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No pathways have been reviewed or authored by MDM2 SUMOylates TP53 with SUMO2,3 (2997706)