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Details on Person PIAS1,4 SUMOylates BRCA1 with SUMO2,3

Class:Id	Reaction:2997616
_displayName	PIAS1,4 SUMOylates BRCA1 with SUMO2,3
_doRelease	TRUE
_timestamp	2022-01-18 18:46:34
authored	[InstanceEdit:2993796] May, B, 2013-01-19
catalystActivity	[CatalystActivity:2997675] SUMO transferase activity of PIAS1,4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2997618] May, B, 2013-01-23
edited	[InstanceEdit:2993796] May, B, 2013-01-19
input	[EntityWithAccessionedSequence:50949] BRCA1 [nucleoplasm] [Homo sapiens] [DefinedSet:3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] [Homo sapiens] [DefinedSet:3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2997586] Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks [LiteratureReference:2997575] The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress [LiteratureReference:2997688] Cell cycle-dependent conjugation of endogenous BRCA1 protein with SUMO-2/3 [LiteratureReference:5626896] Uncovering global SUMOylation signaling networks in a site-specific manner
modified	[InstanceEdit:3065680] May, B, 2013-02-06 [InstanceEdit:3730756] May, B, 2013-06-15 [InstanceEdit:3899313] May, B, 2013-07-12 [InstanceEdit:4663810] May, B, 2013-10-06 [InstanceEdit:5626908] May, Bruce, 2014-10-13 [InstanceEdit:5677004] May, Bruce, 2015-02-21 [InstanceEdit:9762188] May, Bruce, 2022-01-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 Conjugation of SUMO2,3 to BRCA1
output	[EntityWithAccessionedSequence:2997624] polySUMO2,3-BRCA1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993790] Transfer of SUMO2 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2993784] Conjugation of SUMO2 to UBA2:SAE1 [Homo sapiens] [Reaction:2993769] Transfer of SUMO3 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2993781] Conjugation of SUMO3 to UBA2:SAE1 [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5677000] Ferrari, Stefano, 2015-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5679739] R-HSA-2997616.3
summation	[Summation:4663781] PIAS1,4 SUMOylate BRCA1 with SUMO2,3 (Galanty et al. 2009, M...
(hasEvent)	[Pathway:3108214] SUMOylation of DNA damage response and repair proteins [Homo sapiens]
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No pathways have been reviewed or authored by PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (2997616)