Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Both human ANKLE2 and the C. elegans ortholog LEM4 bind VRK1...

Class:IdSummation:2995393
_displayNameBoth human ANKLE2 and the C. elegans ortholog LEM4 bind VRK1...
_timestamp2019-11-27 17:09:55
created[InstanceEdit:2995394] Orlic-Milacic, M, 2013-01-22
modified[InstanceEdit:2997739] Orlic-Milacic, M, 2013-01-23
[InstanceEdit:3058307] Orlic-Milacic, M, 2013-02-06
[InstanceEdit:9667962] Orlic-Milacic, Marija, 2019-11-18
[InstanceEdit:9668552] Orlic-Milacic, Marija, 2019-11-27
textBoth human ANKLE2 and the C. elegans ortholog LEM4 bind VRK1 (and possibly VRK2), the kinase responsible for phosphorylation of BANF1 (BAF) in mitotic prophase, and inhibit VRK1 catalytic activity (Asencio et al. 2012).
(summation)[Reaction:2995389] ANKLE2 binds VRK1,(VRK2) [Homo sapiens]
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