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Details on Person COX10 transforms heme to heme O

Class:Id	Reaction:2995330
_displayName	COX10 transforms heme to heme O
_doRelease	TRUE
_timestamp	2024-03-11 16:47:15
authored	[InstanceEdit:2995335] Jassal, B, 2013-01-22
catalystActivity	[CatalystActivity:2995336] protoheme IX farnesyltransferase activity of COX10(?-443) [mitochondrial inner membrane]
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:2995335] Jassal, B, 2013-01-22
edited	[InstanceEdit:2995335] Jassal, B, 2013-01-22
input	[SimpleEntity:2162257] FPP [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:9853511] heme b [mitochondrial inner membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:2995324] Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant [LiteratureReference:2995351] Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene [LiteratureReference:9854158] Biosynthesis and trafficking of heme o and heme a: new structural insights and their implications for reaction mechanisms and prenylated heme transfer
modified	[InstanceEdit:3288226] Jassal, Bijay, 2013-04-15 [InstanceEdit:3632877] Jassal, Bijay, 2013-05-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9854163] D'Eustachio, Peter, 2023-11-22 [InstanceEdit:9854167] D'Eustachio, Peter, 2023-11-22 [InstanceEdit:9865392] Stephan, Ralf, 2024-03-11 [InstanceEdit:9865398] Stephan, Ralf, 2024-03-11
name	COX10 transforms heme to heme O (2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o
output	[SimpleEntity:159450] PPi [mitochondrial matrix] [SimpleEntity:9865393] heme O [mitochondrial inner membrane]
precedingEvent	[Reaction:189465] FECH binds Fe2+ to PRIN9 to form heme [Homo sapiens] [BlackBoxEvent:189457] Mitochondrial intermembrane PRIN9 translocates to mitochondrial matrix [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-06-11
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15 [InstanceEdit:9865397] Matthews, Lisa, 2024-03-11
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654249] R-HSA-2995330.4
structureModified	[InstanceEdit:9865392] Stephan, Ralf, 2024-03-11
summation	[Summation:2995359] Heme A and less frequently heme O function as prosthetic gro...
(hasEvent)	[Pathway:189451] Heme biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:2995334] COX15 transforms heme O to heme A [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864334] Update Tracker - [Reaction:2995330] COX10 transforms heme to heme O - v88:[addLiteratureReference, modifyText] [_UpdateTracker:9911033] Update Tracker - [Reaction:2995330] COX10 transforms heme to heme O - v89:[add_removeInput, add_removeOutput]
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