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Details on Person NEK6/NEK7 phosphorylates NUP98

Class:IdReaction:2990880
_displayNameNEK6/NEK7 phosphorylates NUP98
_doReleaseTRUE
_timestamp2017-12-06 21:17:03
authored[InstanceEdit:2990898] Orlic-Milacic, M, 2013-01-17
catalystActivity[CatalystActivity:2990918] protein serine/threonine kinase activity of p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol]
compartment[Compartment:13231] nuclear envelope
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created[InstanceEdit:2990898] Orlic-Milacic, M, 2013-01-17
edited[InstanceEdit:2997529] Gillespie, ME, 2013-01-23
input[Complex:2990903] Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:2990889] Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry
[LiteratureReference:2993454] Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes
modified[InstanceEdit:2993455] Orlic-Milacic, M, 2013-01-18
[InstanceEdit:3162973] Orlic-Milacic, M, 2013-02-21
[InstanceEdit:3458773] Orlic-Milacic, M, 2013-05-16
[InstanceEdit:3508345] Orlic-Milacic, M, 2013-05-17
[InstanceEdit:3508351] Orlic-Milacic, M, 2013-05-17
[InstanceEdit:8864965] Orlic-Milacic, Marija, 2016-03-17
[InstanceEdit:9032154] Orlic-Milacic, Marija, 2017-12-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNEK6/NEK7 phosphorylates NUP98
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[Complex:2990888] Partially Disassembled NPC [nuclear envelope] [Homo sapiens]
[CandidateSet:2990901] p-4S,3T-NUP98 [cytosol] [Homo sapiens]
[CandidateSet:2990901] p-4S,3T-NUP98 [cytosol] [Homo sapiens]
[CandidateSet:2990901] p-4S,3T-NUP98 [cytosol] [Homo sapiens]
[CandidateSet:2990901] p-4S,3T-NUP98 [cytosol] [Homo sapiens]
[CandidateSet:2990905] p-4S,3T-NUP98 [nucleoplasm] [Homo sapiens]
[CandidateSet:2990905] p-4S,3T-NUP98 [nucleoplasm] [Homo sapiens]
[CandidateSet:2990905] p-4S,3T-NUP98 [nucleoplasm] [Homo sapiens]
[CandidateSet:2990905] p-4S,3T-NUP98 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2013-06-11
reviewed[InstanceEdit:3508348] Antonin, Wolfram, 2013-05-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3654543] R-HSA-2990880.4
summation[Summation:2993452] Phosphorylation of NUP98 by NEK6 (and/or NEK7) promotes nucl...
(hasEvent)[Pathway:3301854] Nuclear Pore Complex (NPC) Disassembly [Homo sapiens]
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