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Details on Person NEK6/NEK7 phosphorylates NUP98
Class:Id Reaction:2990880
_displayName NEK6/NEK7 phosphorylates NUP98
_doRelease TRUE
_timestamp 2017-12-06 21:17:03
authored [InstanceEdit:2990898] Orlic-Milacic, M, 2013-01-17
catalystActivity [CatalystActivity:2990918] protein serine/threonine kinase activity of p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol]
compartment [Compartment:13231] nuclear envelope [Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created [InstanceEdit:2990898] Orlic-Milacic, M, 2013-01-17
edited [InstanceEdit:2997529] Gillespie, ME, 2013-01-23
input [Complex:2990903] Nuclear Pore Complex (p-2S,3T-NUP98) [nuclear envelope] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric FALSE
literatureReference [LiteratureReference:2990889] Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry [LiteratureReference:2993454] Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes
modified [InstanceEdit:2993455] Orlic-Milacic, M, 2013-01-18 [InstanceEdit:3162973] Orlic-Milacic, M, 2013-02-21 [InstanceEdit:3458773] Orlic-Milacic, M, 2013-05-16 [InstanceEdit:3508345] Orlic-Milacic, M, 2013-05-17 [InstanceEdit:3508351] Orlic-Milacic, M, 2013-05-17 [InstanceEdit:8864965] Orlic-Milacic, Marija, 2016-03-17 [InstanceEdit:9032154] Orlic-Milacic, Marija, 2017-12-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name NEK6/NEK7 phosphorylates NUP98
output [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:2990888] Partially Disassembled NPC [nuclear envelope] [Homo sapiens] [CandidateSet:2990901] p-4S,3T-NUP98 [cytosol] [Homo sapiens] [CandidateSet:2990901] p-4S,3T-NUP98 [cytosol] [Homo sapiens] [CandidateSet:2990901] p-4S,3T-NUP98 [cytosol] [Homo sapiens] [CandidateSet:2990901] p-4S,3T-NUP98 [cytosol] [Homo sapiens] [CandidateSet:2990905] p-4S,3T-NUP98 [nucleoplasm] [Homo sapiens] [CandidateSet:2990905] p-4S,3T-NUP98 [nucleoplasm] [Homo sapiens] [CandidateSet:2990905] p-4S,3T-NUP98 [nucleoplasm] [Homo sapiens] [CandidateSet:2990905] p-4S,3T-NUP98 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate 2013-06-11
reviewed [InstanceEdit:3508348] Antonin, Wolfram, 2013-05-17
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:3654543] R-HSA-2990880.4
summation [Summation:2993452] Phosphorylation of NUP98 by NEK6 (and/or NEK7) promotes nucl...
(hasEvent) [Pathway:3301854] Nuclear Pore Complex (NPC) Disassembly [Homo sapiens]
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