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Details on Person Conjugation of SUMO1 to UBA2:SAE1

Class:IdReaction:2990833
_displayNameConjugation of SUMO1 to UBA2:SAE1
_doReleaseTRUE
_timestamp2013-06-14 01:23:48
authored[InstanceEdit:2984266] May, B, 2013-01-16
catalystActivity[CatalystActivity:2993766] SUMO activating enzyme activity of UBA2:SAE1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:2990847] May, B, 2013-01-17
edited[InstanceEdit:2984266] May, B, 2013-01-16
input[Complex:2990843] UBA2:SAE1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[EntityWithAccessionedSequence:877304] SUMO1 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3215001] Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1
[LiteratureReference:3214984] In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2
[LiteratureReference:3214967] Performing in vitro sumoylation reactions using recombinant enzymes
[LiteratureReference:3299571] Role of the Zn(2+) motif of E1 in SUMO adenylation
[LiteratureReference:3299585] Active site remodelling accompanies thioester bond formation in the SUMO E1
modified[InstanceEdit:2993796] May, B, 2013-01-19
[InstanceEdit:3065680] May, B, 2013-02-06
[InstanceEdit:3215024] May, B, 2013-03-14
[InstanceEdit:3222564] May, B, 2013-03-23
[InstanceEdit:3299598] May, B, 2013-04-19
[InstanceEdit:3448699] May, B, 2013-05-16
[InstanceEdit:3465557] May, B, 2013-05-17
[InstanceEdit:3730631] May, B, 2013-06-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameConjugation of SUMO1 to UBA2:SAE1
output[SimpleEntity:164121] AMP [nucleoplasm]
[SimpleEntity:113541] PPi [nucleoplasm]
[Complex:2993793] SUMO1:UBA2:SAE1 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2013-06-11
reviewed[InstanceEdit:3448698] Garg, Amit K, 2013-05-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3654465] R-HSA-2990833.2
summation[Summation:3222554] The UBA2:SAE1 complex catalyzes the formation of a thioester...
(hasEvent)[Pathway:3065676] SUMO is conjugated to E1 (UBA2:SAE1) [Homo sapiens]
(inferredFrom)[Reaction:2993781] Conjugation of SUMO3 to UBA2:SAE1 [Homo sapiens]
[Reaction:2993784] Conjugation of SUMO2 to UBA2:SAE1 [Homo sapiens]
(precedingEvent)[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens]
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