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Details on Person CDK1:CCNB phosphorylates NEK9

Class:IdReaction:2984220
_displayNameCDK1:CCNB phosphorylates NEK9
_doReleaseTRUE
_timestamp2017-12-06 21:17:03
authored[InstanceEdit:2995320] Orlic-Milacic, M, 2013-01-21
catalystActivity[CatalystActivity:2311326] cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:2984221] Orlic-Milacic, M, 2013-01-15
edited[InstanceEdit:2997529] Gillespie, ME, 2013-01-23
input[Complex:2984219] p-T333-NEK9 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:2980764] Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression
[LiteratureReference:2984212] Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5
[LiteratureReference:2984208] Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly
modified[InstanceEdit:2984235] Orlic-Milacic, M, 2013-01-15
[InstanceEdit:3132747] Orlic-Milacic, M, 2013-02-12
[InstanceEdit:9032154] Orlic-Milacic, Marija, 2017-12-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCDK1:CCNB phosphorylates NEK9
output[Complex:2984215] p-3S,T-NEK9 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2013-03-12
reviewed[InstanceEdit:3132746] Avruch, Joseph, 2013-02-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200494] R-HSA-2984220.3
summation[Summation:2984232] NEK9 functions as a homodimer and becomes catalytically acti...
(hasEvent)[Pathway:2980767] Activation of NIMA Kinases NEK9, NEK6, NEK7 [Homo sapiens]
(precedingEvent)[Reaction:2984226] PLK1 phosphorylates NEK9 [Homo sapiens]
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