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Details on Person MDK (Midkine, MK) is a secreted, heparin-binding growth fact...
| Class:Id | Summation:2974751 |
|---|---|
| _displayName | MDK (Midkine, MK) is a secreted, heparin-binding growth fact... |
| _timestamp | 2013-05-15 14:34:47 |
| created | [InstanceEdit:2974745] Orlic-Milacic, M, 2013-01-07 |
| modified | [InstanceEdit:2978083] Orlic-Milacic, M, 2013-01-10 [InstanceEdit:2980675] Orlic-Milacic, M, 2013-01-11 [InstanceEdit:2984198] Orlic-Milacic, M, 2013-01-15 [InstanceEdit:3446778] Orlic-Milacic, M, 2013-05-15 |
| text | MDK (Midkine, MK) is a secreted, heparin-binding growth factor that acts as a homodimer (Iwasaki et al. 1997). Both the full-length and the C-terminal region of MDK can bind the N-terminus of NOTCH2. In the presence of MDK, NICD2 accumulates in the nucleus in a dose-dependent fashion and epithelial-to-mesenchymal-transition (EMT) morphological changes are induced through a mechanism that has not been fully elucidated (Huang et al. 2008, Gungor et al. 2011). |
| (summation) | [Reaction:2974737] NOTCH2 binds MDK [Homo sapiens] |
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No pathways have been reviewed or authored by MDK (Midkine, MK) is a secreted, heparin-binding growth fact... (2974751)
