Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NOTCH2 binds MDK

Class:IdReaction:2974737
_displayNameNOTCH2 binds MDK
_doReleaseTRUE
_timestamp2013-05-31 09:49:16
authored[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:2974745] Orlic-Milacic, M, 2013-01-07
edited[InstanceEdit:3159303] Haw, R, 2013-01-14
input[Complex:2974753] MDK [extracellular region] [Homo sapiens]
[Complex:157005] NOTCH2 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2974758] Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes
[LiteratureReference:2974760] Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer
[LiteratureReference:2974742] Solution structure of midkine, a new heparin-binding growth factor
modified[InstanceEdit:2980008] Orlic-Milacic, M, 2013-01-10
[InstanceEdit:3446783] Orlic-Milacic, M, 2013-05-15
[InstanceEdit:3446784] Orlic-Milacic, M, 2013-05-15
[InstanceEdit:3448658] Orlic-Milacic, M, 2013-05-15
[InstanceEdit:3451015] Orlic-Milacic, M, 2013-05-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNOTCH2 binds MDK
output[Complex:2974762] MDK:NOTCH2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2013-06-11
reviewed[InstanceEdit:3448657] Boyle, Scott, 2013-04-25
[InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3654511] R-HSA-2974737.2
summation[Summation:2974751] MDK (Midkine, MK) is a secreted, heparin-binding growth fact...
(hasEvent)[Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(replacementInstances)[_Deleted:5694726] Deletion of instance: 157083
[_Deleted:5694728] Deletion of instance: 157651
[Change default viewing format]
No pathways have been reviewed or authored by NOTCH2 binds MDK (2974737)