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Details on Person POU5F1 (OCT4), SOX2, NANOG bind the LEFTY2 promoter

Class:Id	Reaction:2972963
_displayName	POU5F1 (OCT4), SOX2, NANOG bind the LEFTY2 promoter
_doRelease	FALSE
_timestamp	2016-07-15 23:49:22
authored	[InstanceEdit:2901807] May, B, 2013-01-03
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2972945] D'Eustachio, P, 2013-01-06
edited	[InstanceEdit:2901807] May, B, 2013-01-03
input	[EntityWithAccessionedSequence:2888988] LEFTY2 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452586] NANOG [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452472] POU5F1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452271] SOX2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
modified	[InstanceEdit:3108239] May, B, 2013-02-10 [InstanceEdit:3165216] May, B, 2013-02-22 [InstanceEdit:4411347] May, B, 2013-08-23 [InstanceEdit:4420242] May, B, 2013-08-31 [InstanceEdit:5159238] D'Eustachio, P, 2013-11-22 [InstanceEdit:5251385] May, B, 2014-02-03 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	POU5F1 (OCT4), SOX2, NANOG bind the LEFTY2 promoter
output	[Complex:2889027] OCT4:SOX2:NANOG:LEFTY2 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:452838] Expression of NANOG [Homo sapiens] [Reaction:480204] POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter [Homo sapiens] [BlackBoxEvent:452894] Expression of SOX2 [Homo sapiens] [Reaction:480685] POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter [Homo sapiens] [BlackBoxEvent:2889036] Translation of OCT4 mRNA [Homo sapiens] [Reaction:500366] LIN28 binds POU5F1 (OCT4) mRNA [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8892776] R-HSA-2972963.1
summation	[Summation:2972893] POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the LEFT...
(hasEvent)	[Pathway:500407] Individual Binding Reactions and Reactions Regulated by Pluripotency Factors [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:452384] Expression of TGF beta 4 (LEFTY2) [Homo sapiens]
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No pathways have been reviewed or authored by POU5F1 (OCT4), SOX2, NANOG bind the LEFTY2 promoter (2972963)