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Details on Person POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter

Class:IdReaction:2972949
_displayNamePOU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter
_doReleaseTRUE
_timestamp2014-11-20 02:40:36
authored[InstanceEdit:2901807] May, B, 2013-01-03
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:2972945] D'Eustachio, P, 2013-01-06
edited[InstanceEdit:2901807] May, B, 2013-01-03
input[EntityWithAccessionedSequence:2888969] EOMES gene [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:452586] NANOG [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:452472] POU5F1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:452271] SOX2 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells
[LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
[LiteratureReference:1112612] A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells
[LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin
[LiteratureReference:5246719] Human DNA methylomes at base resolution show widespread epigenomic differences
[LiteratureReference:5250252] Transposable elements have rewired the core regulatory network of human embryonic stem cells
[LiteratureReference:5251124] Eomesodermin is required for mouse trophoblast development and mesoderm formation
[LiteratureReference:5251136] Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin
modified[InstanceEdit:2972985] D'Eustachio, P, 2013-01-06
[InstanceEdit:2975872] May, B, 2013-01-09
[InstanceEdit:3108239] May, B, 2013-02-10
[InstanceEdit:3165216] May, B, 2013-02-22
[InstanceEdit:4411347] May, B, 2013-08-23
[InstanceEdit:4420242] May, B, 2013-08-31
[InstanceEdit:5159238] D'Eustachio, P, 2013-11-22
[InstanceEdit:5250254] May, B, 2014-01-24
[InstanceEdit:5250255] May, B, 2014-01-24
[InstanceEdit:5251221] May, B, 2014-01-31
[InstanceEdit:5251384] May, B, 2014-02-03
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePOU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter
output[Complex:2889000] POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2014-03-12
reviewed[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644555] R-HSA-2972949.2
summation[Summation:2972903] The EOMES gene is bound by POU5F1 (OCT4) (Boyer et al. 2005,...
(hasEvent)[Pathway:2892245] POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation [Homo sapiens]
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