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Details on Person NOTCH1 HD+PEST domain mutants bind JAG1

Class:Id	Reaction:2900743
_displayName	NOTCH1 HD+PEST domain mutants bind JAG1
_doRelease	TRUE
_timestamp	2018-12-12 17:27:06
authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2900750] Orlic-Milacic, M, 2013-01-03
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:9632007] gain_of_function of NOTCH1 HD+PEST Domain Mutants [plasma membrane]
entityOnOtherCell	[EntityWithAccessionedSequence:157098] JAG1 [plasma membrane] [Homo sapiens]
input	[EntityWithAccessionedSequence:157098] JAG1 [plasma membrane] [Homo sapiens] [CandidateSet:2894870] NOTCH1 HD+PEST Domain Mutants [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2691227] Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
modified	[InstanceEdit:3110289] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3110297] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:9632008] Orlic-Milacic, Marija, 2018-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 HD+PEST domain mutants bind JAG1
normalReaction	[Reaction:1980042] NOTCH1 binds JAG1 [Homo sapiens]
output	[Complex:2900751] JAG1:NOTCH1 HD+PEST Domain Mutants [plasma membrane] [Homo sapiens]
releaseDate	2012-03-12
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200447] R-HSA-2900743.3
summation	[Summation:2900752] It has not been directly shown that JAG1 binds to and activa...
(hasEvent)	[Pathway:2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Homo sapiens]
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No pathways have been reviewed or authored by NOTCH1 HD+PEST domain mutants bind JAG1 (2900743)