Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

Class:IdPathwayDiagram:2895784
_displayNameDiagram of POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
_timestamp2016-09-19 08:41:21
created[InstanceEdit:2895783] May, B, 2013-01-03
height1084
modified[InstanceEdit:2974734] May, B, 2013-01-07
[InstanceEdit:2974735] May, B, 2013-01-07
[InstanceEdit:3050612] Jassal, B, 2013-02-06
[InstanceEdit:3632186] May, B, 2013-05-25
[InstanceEdit:4411347] May, B, 2013-08-23
[InstanceEdit:5159237] D'Eustachio, P, 2013-11-22
[InstanceEdit:5163275] May, B, 2013-11-24
[InstanceEdit:5185722] May, B, 2013-11-29
[InstanceEdit:5250255] May, B, 2014-01-24
[InstanceEdit:5251384] May, B, 2014-02-03
[InstanceEdit:5638458] May, Bruce, 2014-11-15
[InstanceEdit:6800074] May, Bruce, 2015-09-27
[InstanceEdit:6800077] May, Bruce, 2015-09-27
[InstanceEdit:6800126] May, Bruce, 2015-09-28
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8939428] May, Bruce, 2016-09-19
[InstanceEdit:9645116] Wu, G, 2019-05-03
representedPathway[Pathway:2892247] POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="125752" reactomeDiagramId="2895784" hideCompartmentInName="true"> <Nodes> <org.gk.render.RenderableCompartment id="2" reactomeId="70101" position="835 521" bounds="25 18 1620 1006" textPosition="39 919" bgColor="250 240 240" lineColor="255 153 102" insets="35 33 1598 922"> <Components> <Component id="45" /> <Component id="48" /> <Component id="7" /> <Component id="3" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="3" reactomeId="7660" position="827 435" bounds="53 52 1548 766" textPosition="74 83" bgColor="250 240 240" lineColor="255 153 102" insets="64 59 1525 749"> <Components> <Component id="6" /> <Component id="15" /> <Component id="17" /> <Component id="18" /> <Component id="19" /> <Component id="44" /> <Component id="47" /> <Component id="54" /> <Component id="55" /> <Component id="53" /> <Component id="69" /> <Component id="70" /> <Component id="71" /> <Component id="72" /> <Component id="73" /> <Component id="88" /> <Component id="89" /> <Component id="104" /> <Component id="105" /> <Component id="113" /> <Component id="114" /> <Component id="117" /> <Component id="118" /> <Component id="131" /> <Component id="132" /> <Component id="137" /> <Component id="5" /> <Component id="46" /> <Component id="14" /> <Component id="43" /> <Component id="153" /> <Component id="154" /> <Component id="155" /> <Component id="157" /> <Component id="158" /> <Component id="156" /> <Component id="162" /> <Component id="163" /> <Component id="164" /> <Component id="165" /> <Component id="166" /> <Component id="167" /> <Component id="168" /> <Component id="169" /> <Component id="173" /> <Component id="174" /> <Component id="175" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="6" reactomeId="2889014" position="606 634" bounds="535 613 142 42" textPosition="535 620" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="7" reactomeId="211415" position="548 992" bounds="518 977 61 30" textPosition="525 981" /> <org.gk.render.RenderableComplex id="15" reactomeId="2889015" position="1051 631" bounds="1002 607 99 48" textPosition="1005 606" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="16" reactomeId="189898" position="1043 1060" bounds="988 1045 111 31" textPosition="997 1050" /> <org.gk.render.RenderableComplex id="18" reactomeId="2889032" position="272 404" bounds="205 385 135 38" textPosition="208 388" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="19" reactomeId="452918" position="149 634" bounds="120 623 59 22" textPosition="125 623" /> <org.gk.render.RenderableComplex id="44" reactomeId="2889003" position="1267 651" bounds="1218 626 98 51" textPosition="1218 628" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="45" reactomeId="539044" position="1273 880" bounds="1246 868 54 24" textPosition="1250 869" /> <org.gk.render.RenderableComplex id="47" reactomeId="2889018" position="858 631" bounds="786 612 145 38" textPosition="788 615" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="48" reactomeId="452300" position="789 989" bounds="611 969 356 41" textPosition="629 972"> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0449438202247191" relativeY="0.0" label="PI" trackId="0" reactomeId="1226042" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="54" reactomeId="2889030" position="1504 311" bounds="1443 292 122 39" textPosition="1447 296" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="55" reactomeId="480800" position="1509 488" bounds="1481 476 56 24" textPosition="1492 477" /> <org.gk.render.RenderableProtein id="70" reactomeId="452472" position="864 79" bounds="832 66 65 26" textPosition="837 68" /> <org.gk.render.RenderableProtein id="71" reactomeId="452586" position="691 87" bounds="664 73 55 29" textPosition="665 77" /> <org.gk.render.RenderableGene id="72" reactomeId="2888982" position="480 545" bounds="441 520 79 51" textPosition="441 547" /> <org.gk.render.RenderableProtein id="73" reactomeId="452271" position="1053 82" bounds="1029 68 49 28" textPosition="1034 71" /> <org.gk.render.RenderableGene id="89" reactomeId="2888992" position="115 341" bounds="68 316 95 51" textPosition="75 343" /> <org.gk.render.RenderableGene id="105" reactomeId="2888979" position="1368 260" bounds="1329 235 79 51" textPosition="1335 262" /> <org.gk.render.RenderableGene id="114" reactomeId="2888995" position="1144 511" bounds="1117 486 54 51" textPosition="1119 513" /> <org.gk.render.RenderableGene id="118" reactomeId="2888971" position="940 530" bounds="911 505 59 51" textPosition="920 532" /> <org.gk.render.RenderableGene id="132" reactomeId="2888987" position="717 550" bounds="667 518 100 65" textPosition="677 545" /> <org.gk.render.RenderableComplex id="137" reactomeId="2892230" position="897 745" bounds="846 728 102 35" textPosition="850 728" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableGene id="154" reactomeId="2888989" position="1369 502" bounds="1329 491 81 22" textPosition="1332 518" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0" /> <org.gk.render.RenderableComplex id="155" reactomeId="2889029" position="1448 598" bounds="1381 577 134 42" textPosition="1387 584" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="157" reactomeId="452500" position="1454 758" bounds="1427 744 55 28" textPosition="1433 747" /> <org.gk.render.RenderableComplex id="158" reactomeId="2889010" position="1513 681" bounds="1485 654 57 54" textPosition="1490 659" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableGene id="163" reactomeId="6800123" position="251 485" bounds="208 460 87 51" textPosition="212 487" /> <org.gk.render.RenderableComplex id="164" reactomeId="6800114" position="371 570" bounds="320 545 103 50" textPosition="322 546" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="166" reactomeId="452999" position="303 790" bounds="278 779 51 22" textPosition="280 779" /> <org.gk.render.RenderableGene id="168" reactomeId="8939415" position="143 137" bounds="96 112 94 51" textPosition="105 139" /> <org.gk.render.RenderableComplex id="169" reactomeId="8939420" position="312 172" bounds="242 160 140 25" textPosition="250 164" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="174" reactomeId="452672" position="191 267" bounds="162 256 59 23" textPosition="169 257" /> <org.gk.render.RenderableComplex id="175" reactomeId="480182" position="311 209" bounds="217 198 189 22" textPosition="233 199" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="5" reactomeId="480509" points="529 522, 528 669, 589 739, 550 974" position="589 739" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="72" /> </Inputs> <Outputs> <Output id="7" /> </Outputs> <Activators> <Activator id="6" points="602 658" /> </Activators> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14" reactomeId="480515" points="979 507, 986 683, 1039 767, 1042 1042" position="1039 767" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="118" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Activators> <Activator id="15" points="1048 658" /> </Activators> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="452750" points="172 318, 170 404, 150 620" position="170 404" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="89" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Activators> <Activator id="18" points="202 404" /> </Activators> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="43" reactomeId="452515" points="1180 488, 1190 691, 1269 766, 1272 865" position="1269 766" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="114" /> </Inputs> <Outputs> <Output id="45" /> </Outputs> <Activators> <Activator id="44" points="1267 680" /> </Activators> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="46" reactomeId="452338" points="776 520, 779 694, 818 746, 819 810, 792 966" position="818 746" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="132" /> </Inputs> <Outputs> <Output id="48" /> </Outputs> <Inhibitors> <Inhibitor id="137" points="843 745" /> </Inhibitors> <Activators> <Activator id="47" points="851 653" /> </Activators> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="53" reactomeId="480470" points="1417 237, 1447 382, 1504 407, 1508 473" position="1504 407" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="105" /> </Inputs> <Outputs> <Output id="55" /> </Outputs> <Activators> <Activator id="54" points="1504 334" /> </Activators> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="69" reactomeId="2972967" points="605 528, 604 566, 605 610" position="604 566" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="70" points="856 95" /> <Input id="71" points="688 105" /> <Input id="72" points="529 522" /> <Input id="73" points="1038 99" /> </Inputs> <Outputs> <Output id="6" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="2972964" points="273 320, 270 347, 271 382" position="270 347" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="70" points="841 95, 460 311" /> <Input id="71" points="675 105, 460 303" /> <Input id="89" points="172 318" /> <Input id="73" points="1026 91, 460 320" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="104" reactomeId="2972978" points="1506 235, 1505 260, 1504 289" position="1505 260" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="70" points="900 86, 1289 183" /> <Input id="71" points="722 91, 1289 192" /> <Input id="73" points="1081 91, 1289 174" /> <Input id="105" points="1417 237" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="2972956" points="1266 515, 1267 559, 1267 623" position="1267 559" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="114" points="1180 488" /> <Input id="70" points="875 95" /> <Input id="71" points="710 105" /> <Input id="73" points="1059 99" /> </Inputs> <Outputs> <Output id="44" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="117" reactomeId="2972960" points="1053 513, 1048 558, 1050 604" position="1048 558" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="70" points="869 95" /> <Input id="71" points="703 105" /> <Input id="118" points="979 507" /> <Input id="73" points="1053 99" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="131" reactomeId="2972962" points="850 537, 851 581, 855 609" position="851 581" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="132" points="776 520" /> <Input id="70" points="863 95" /> <Input id="71" points="696 105" /> <Input id="73" points="1046 99" /> </Inputs> <Outputs> <Output id="47" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="2972975" points="1444 499, 1444 529, 1446 574" position="1444 529" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="154" points="1419 493" /> <Input id="70" points="881 95" /> <Input id="73" points="1066 99" /> <Input id="71" points="717 105" /> </Inputs> <Outputs> <Output id="155" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="156" reactomeId="452958" points="1419 493, 1374 637, 1451 682, 1453 741" position="1451 682" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="154" /> </Inputs> <Outputs> <Output id="157" /> </Outputs> <Inhibitors> <Inhibitor id="158" points="1482 681" /> </Inhibitors> <Activators> <Activator id="155" points="1448 622" /> </Activators> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="162" reactomeId="6800120" points="371 478, 373 504, 371 542" position="373 504" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="73" points="1026 96" /> <Input id="70" points="847 95" /> <Input id="71" points="679 105" /> <Input id="163" points="304 462" /> </Inputs> <Outputs> <Output id="164" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="165" reactomeId="452701" points="304 462, 305 678, 303 776" position="305 678" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="163" /> </Inputs> <Outputs> <Output id="166" /> </Outputs> <Activators> <Activator id="164" points="355 598" /> </Activators> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="167" reactomeId="8939417" points="301 114, 304 135, 309 157" position="304 135" lineWidth="1.0"> <Inputs> <Input id="71" points="661 88" /> <Input id="168" points="199 114" /> </Inputs> <Outputs> <Output id="169" /> </Outputs> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="173" reactomeId="480644" points="199 114, 197 179, 191 253" position="197 179" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="168" /> </Inputs> <Outputs> <Output id="174" /> </Outputs> <Activators> <Activator id="175" points="269 195" /> <Activator id="169" points="239 176" /> </Activators> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
width1653
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (2895784)
Follow Reactome