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Details on Person Syndecans are type I transmembrane proteins, with an N-termi...
| Class:Id | Summation:2867921 |
|---|---|
| _displayName | Syndecans are type I transmembrane proteins, with an N-termi... |
| _timestamp | 2012-12-19 17:29:26 |
| created | [InstanceEdit:2867920] Jupe, S, 2012-12-19 |
| literatureReference | [LiteratureReference:2682240] Syndecans: new kids on the signaling block [LiteratureReference:2684472] Heparan sulfate proteoglycans from mouse mammary epithelial cells. Cell surface proteoglycan as a receptor for interstitial collagens [LiteratureReference:2684478] The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells [LiteratureReference:2684471] Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts [LiteratureReference:2684483] Laminin alpha1 chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin alpha2beta1 [LiteratureReference:2684503] The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain [LiteratureReference:2731135] Syndecan-1 supports integrin alpha2beta1-mediated adhesion to collagen [LiteratureReference:2682228] Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4 [LiteratureReference:2682312] Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice [LiteratureReference:2682286] Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature |
| modified | [InstanceEdit:2867922] Jupe, S, 2012-12-19 |
| text | Syndecans are type I transmembrane proteins, with an N-terminal ectodomain that contains several consensus sequences for glycosaminoglycan (GAG) attachment and a short C-terminal cytoplasmic domain. Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005). HS chains facilitate interactions of syndecan-1 with extracellular matrix proteins, including several types of collagen (type I, III and V - Koda et al. 1985). It is thought that syndecans often act in concert with other receptors, e.g. alphavbeta3 and alphavbeta5 integrins cooperate with syndecan-1 during adhesion to vitronectin (Beauvais et al. 2004, McQuade et al. 2006) while alpha2beta1 and alpha6beta4 integrins cooperate with syndecans during adhesion to laminin (laminin alpha-1 Hozumi et al. 2006, laminin gamma-2, Ogawa et al. 2007). Similarly syndecan-1 appears to support integrin alpha2Beta1-mediated adhesion to collagen (human to cow collagen I - Vuoriluoto et al. 2008). This relationship between syndecans and co-receptors is not well understood (Alexopoulou et al. 2007). Syndecan-null mice have subtle phenotypes when compared with mice deficient in HS chain synthesis or modification (Echtermeyer et al. 2001, Ishiquro et al. 2001, Götte et al. 2002). |
| (summation) | [Reaction:2731094] Syndecan-1 binds collagen types I, III, V [Gallus gallus] |
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