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Details on Person Ficolin-1 (M-ficolin or FCN1) was shown to localize at the c...
| Class:Id | Summation:2855103 |
|---|---|
| _displayName | Ficolin-1 (M-ficolin or FCN1) was shown to localize at the c... |
| _timestamp | 2013-05-24 16:53:51 |
| created | [InstanceEdit:2855135] Shamovsky, V, 2012-12-17 |
| modified | [InstanceEdit:3266559] Shamovsky, V, 2013-04-10 [InstanceEdit:3301202] Shamovsky, V, 2013-04-22 [InstanceEdit:3301223] Shamovsky, V, 2013-04-22 [InstanceEdit:3621850] Shamovsky, V, 2013-05-24 |
| text | Ficolin-1 (M-ficolin or FCN1) was shown to localize at the cell surface of circulating monocytes and granulocytes, despite lacking an obvious transmembrane domain, (Teh C et al. 2000; Honore C et al. 2010). Ficolin-1 has also been found in human plasma (Honore C et al. 2008; Wittenborn T et al. 2010; Kjaer TR et al. 2011). Monocytes and macrophages, but not immature dendritic cells were reported to secrete Ficolin-1 into the serum (Honore C et al. 2010). Moreover, early studies revealed its presence in secretory granules of peripheral blood monocytes and granulocytes (Liu Y et al. 2005). Soluble Ficolin-1 was found to form a complex with MASP2, while cell surface-bound Ficolin-1 did not associate with MASP (Honore C et al. 2010; Kjaer TR et al. 2011). Ficolin-1 specifically recognizes sialic acid and can bind to acetylated compounds such as N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) (Garlatti V et al. 2007; Gout E et al. 2010; Kjaer TR et al. 2011). |
| (summation) | [Reaction:2855125] Ficolin-1 binds to molecular patterns on the target cell surface [Homo sapiens] |
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