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Details on Person Ficolin-2 binds to molecular patterns on the target cell surface

Class:Id	Reaction:2855054
_displayName	Ficolin-2 binds to molecular patterns on the target cell surface
_doRelease	TRUE
_timestamp	2013-05-31 09:40:22
authored	[InstanceEdit:2530435] Shamovsky, V, 2012-10-17
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2855135] Shamovsky, V, 2012-12-17
edited	[InstanceEdit:3632872] Shamovsky, V, 2013-05-28
input	[SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [DefinedSet:2855063] FCN2 ligands [plasma membrane] [Complex:2855087] FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:2173389] Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin [LiteratureReference:2173434] Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins [LiteratureReference:2855071] Structural insights into the innate immune recognition specificities of L- and H-ficolins [LiteratureReference:2855058] Structural insights into the recognition properties of human ficolins [LiteratureReference:2855096] L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement [LiteratureReference:2855141] L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway [LiteratureReference:2855131] Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement [LiteratureReference:2855108] Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation [LiteratureReference:2855089] Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease
modified	[InstanceEdit:3266559] Shamovsky, V, 2013-04-10 [InstanceEdit:3465580] Shamovsky, V, 2013-05-17 [InstanceEdit:3632872] Shamovsky, V, 2013-05-28 [InstanceEdit:3640606] Shamovsky, V, 2013-05-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ficolin-2 binds to molecular patterns on the target cell surface
output	[Complex:2855065] FCN2 ligands:FCN2 dodecamer:MASP1 dimer:MASP2-1 dimer:4xCa2+ [plasma membrane] [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3632871] Bradley, DT
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654291] R-HSA-2855054.2
summation	[Summation:2855091] Human ficolin-2 (L-ficolin, P35, FCN2) is synthesised in the...
(hasEvent)	[Pathway:2855086] Ficolins bind to repetitive carbohydrate structures on the target cell surface [Homo sapiens]
(precedingEvent)	[Reaction:166726] Activation of MASPs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783450] Update Tracker - [Reaction:2855054] Ficolin-2 binds to molecular patterns on the target cell surface - v56:[modifyText]
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