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Details on Person NICD1 PEST domain mutants translocate from cytosol to nucleus

Class:IdReaction:2769015
_displayNameNICD1 PEST domain mutants translocate from cytosol to nucleus
_doReleaseTRUE
_timestamp2016-03-29 14:19:36
authored[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
compartment[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created[InstanceEdit:2769014] Orlic-Milacic, M, 2012-12-10
disease[Disease:1485587] T-cell acute lymphoblastic leukemia
[Disease:1500689] cancer
edited[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus[EntityFunctionalStatus:2775824] gain_of_function of NICD1 PEST Domain Mutants [cytosol]
input[DefinedSet:2220987] NICD1 PEST Domain Mutants [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:159104] Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos
[LiteratureReference:159105] Nuclear access and action of notch in vivo
modified[InstanceEdit:2775828] Orlic-Milacic, M, 2012-12-10
[InstanceEdit:2916618] Orlic-Milacic, M, 2013-01-04
[InstanceEdit:2981002] Orlic-Milacic, M, 2013-01-14
[InstanceEdit:3110289] Orlic-Milacic, M, 2013-02-11
[InstanceEdit:3110297] Orlic-Milacic, M, 2013-02-11
[InstanceEdit:3168184] Orlic-Milacic, M, 2013-02-23
[InstanceEdit:8866034] Orlic-Milacic, Marija, 2016-03-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNICD1 PEST domain mutants translocate from cytosol to nucleus
normalReaction
output[DefinedSet:2769016] NICD1 PEST Domain Mutants [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2012-03-12
reviewed[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200405] R-HSA-2769015.3
summation[Summation:2769012] Cytosolic NICD1 PEST domain mutants are expected to transloc...
(hasEvent)[Pathway:2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants [Homo sapiens]
[Pathway:2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Homo sapiens]
(precedingEvent)[Reaction:2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) [Homo sapiens]
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No pathways have been reviewed or authored by NICD1 PEST domain mutants translocate from cytosol to nucleus (2769015)
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