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Details on Person NOTCH1 PEST domain mutants bind JAG2

Class:Id	Reaction:2768993
_displayName	NOTCH1 PEST domain mutants bind JAG2
_doRelease	TRUE
_timestamp	2018-12-12 17:29:28
authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2769005] Orlic-Milacic, M, 2012-12-10
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:9632010] gain_of_function of NOTCH1 PEST domain mutants [plasma membrane]
entityOnOtherCell	[EntityWithAccessionedSequence:157120] JAG2 [plasma membrane] [Homo sapiens]
input	[CandidateSet:2220939] NOTCH1 PEST domain mutants [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:157120] JAG2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:157224] Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor [LiteratureReference:2053968] Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
modified	[InstanceEdit:2775828] Orlic-Milacic, M, 2012-12-10 [InstanceEdit:2981030] Orlic-Milacic, M, 2013-01-14 [InstanceEdit:3110289] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:3110297] Orlic-Milacic, M, 2013-02-11 [InstanceEdit:6789899] Orlic-Milacic, Marija, 2015-08-05 [InstanceEdit:9632012] Orlic-Milacic, Marija, 2018-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 PEST domain mutants bind JAG2
normalReaction	[Reaction:1980044] NOTCH1 binds JAG2 [Homo sapiens]
output	[Complex:2768998] JAG2:NOTCH1 PEST Domain Mutants [plasma membrane] [Homo sapiens]
releaseDate	2012-03-12
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200190] R-HSA-2768993.4
summation	[Summation:2769001] NOTCH1 PEST domain mutants are expected to bind to JAG2 liga...
(hasEvent)	[Pathway:2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784316] Update Tracker - [Reaction:2768993] NOTCH1 PEST domain mutants bind JAG2 - v54:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by NOTCH1 PEST domain mutants bind JAG2 (2768993)