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Details on Person Osteopontin (SPP1) is a member of the small integrin-binding...

Class:IdSummation:2752135
_displayNameOsteopontin (SPP1) is a member of the small integrin-binding...
_timestamp2013-05-22 14:37:30
created[InstanceEdit:2752107] Jupe, S, 2012-12-07
literatureReference[LiteratureReference:2318667] The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro
[LiteratureReference:215798] Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin
[LiteratureReference:215777] The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin
[LiteratureReference:265369] Osteopontin is a ligand for the alpha4beta1 integrin
[LiteratureReference:2318695] Molecular and cellular biology of osteopontin Potential role in cardiovascular disease
[LiteratureReference:2752116] Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
[LiteratureReference:2318673] CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
[LiteratureReference:3597697] Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
[LiteratureReference:3597705] Reciprocal interactions between tumor-associated macrophages and CD44-positive cancer cells via osteopontin/CD44 promote tumorigenicity in colorectal cancer
modified[InstanceEdit:2867920] Jupe, S, 2012-12-19
[InstanceEdit:3318356] Jupe, S, 2013-04-26
[InstanceEdit:3597687] Jupe, S, 2013-05-22
textOsteopontin (SPP1) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins (Bellahcène et al. 2008). It is a highly phosphorylated sialoprotein and prominent component of the mineralized extracellular matrices of bones and teeth. It binds multiple integrins including alphaVbeta3, alphaVbeta1 and alphaVbeta5 (Liaw et al. 1995) alpha9beta1 (Smith et al. 1996, Yokosaki et al. 1999), alpha4beta1 (Bayliss et al. 1998) and the receptor CD44 (Weber et al. 1996, Katagiri et al. 1999). The SPP1–CD44 interaction may be important for colorectal cancer progression (Rao et al. 2013).
(summation)[Reaction:2752115] SPP1 (osteopontin) binds CD44 [Homo sapiens]
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