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Details on Person Syndecans have attached heparan sulfate (HS) and to a lesser...

Class:IdSummation:2750188
_displayNameSyndecans have attached heparan sulfate (HS) and to a lesser...
_timestamp2013-05-22 10:39:02
created[InstanceEdit:2750182] Jupe, S, 2012-12-06
literatureReference[LiteratureReference:2682306] Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4
[LiteratureReference:2681684] Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region
[LiteratureReference:2682218] Function of the syndecan-4 cytoplasmic domain in oligomerization and association with ?-actinin in turkey muscle satellite cells
[LiteratureReference:2682229] Syndecans in wound healing, inflammation and vascular biology
[LiteratureReference:2682240] Syndecans: new kids on the signaling block
[LiteratureReference:2682228] Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4
[LiteratureReference:2682312] Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice
[LiteratureReference:2682286] Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature
[LiteratureReference:2682296] Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses
modified[InstanceEdit:2867920] Jupe, S, 2012-12-19
[InstanceEdit:3597657] Jupe, S, 2013-05-22
textSyndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005). Syndecan-null mice have subtle phenotypes when compared with mice deficient in HS chain synthesis or modification (Echtermeyer et al. 2001, Ishiquro et al. 2001, Götte et al. 2002). GPI-anchored glypicans and matrix HSPGs such as perlecan may compensate for the absence of syndecans. Syndecans are also signalling molecules, interacting with cytoplasmic proteins. Syndecan-2 binds the kinase Ca2+/calmodulin associated serine/threonine kinase (CASK), a membrane-associated guanylate kinase (MAGUK) associated with intercellular junctions (Hsueh et al. 1998).
(summation)[Reaction:2750184] Syndecan-2 binds Cask [Rattus norvegicus]
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