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Details on Person Syndecans have attached heparan sulfate (HS) and to a lesser...

Class:IdSummation:2750173
_displayNameSyndecans have attached heparan sulfate (HS) and to a lesser...
_timestamp2013-05-22 10:38:55
created[InstanceEdit:2750182] Jupe, S, 2012-12-06
literatureReference[LiteratureReference:2682229] Syndecans in wound healing, inflammation and vascular biology
[LiteratureReference:2682240] Syndecans: new kids on the signaling block
[LiteratureReference:2682228] Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4
[LiteratureReference:2682312] Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice
[LiteratureReference:2682286] Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature
[LiteratureReference:2682242] Syndecan signaling: when, where and why?
[LiteratureReference:2682243] Syndecan-4 associates with alpha-actinin
[LiteratureReference:2682299] The oligomeric status of syndecan-4 regulates syndecan-4 interaction with alpha-actinin
[LiteratureReference:2682218] Function of the syndecan-4 cytoplasmic domain in oligomerization and association with ?-actinin in turkey muscle satellite cells
modified[InstanceEdit:2867920] Jupe, S, 2012-12-19
[InstanceEdit:3597657] Jupe, S, 2013-05-22
textSyndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005). Syndecan-null mice have subtle phenotypes when compared with mice deficient in HS chain synthesis or modification (Echtermeyer et al. 2001, Ishiquro et al. 2001, Götte et al. 2002). GPI-anchored glypicans and matrix HSPGs such as perlecan may compensate for the absence of syndecans.

Syndecans are also signalling molecules, interacting with cytoplasmic proteins. Most of the work done has involved syndecan-4 (Multhaupt et al. 2009). The V-region of syndecan-4 interacts with the actin-bundling protein alpha-actinin (Greene et al. 2003, Choi et al. 2008, Shin et al. 2012), a direct link to the cell cytoskeleton.
(summation)[Reaction:2750176] Syndecan-4 binds Actn1 [Rattus norvegicus]
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