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Details on Person Syndecans have attached heparan sulfate (HS) and to a lesser...

Class:IdSummation:2750172
_displayNameSyndecans have attached heparan sulfate (HS) and to a lesser...
_timestamp2013-05-22 10:38:53
created[InstanceEdit:2750182] Jupe, S, 2012-12-06
literatureReference[LiteratureReference:2682229] Syndecans in wound healing, inflammation and vascular biology
[LiteratureReference:2682240] Syndecans: new kids on the signaling block
[LiteratureReference:2682242] Syndecan signaling: when, where and why?
[LiteratureReference:2731120] Syndecan-4 proteoglycan cytoplasmic domain and phosphatidylinositol 4,5-bisphosphate coordinately regulate protein kinase C activity
[LiteratureReference:2682260] Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates
[LiteratureReference:2682283] Multimerization of the cytoplasmic domain of syndecan-4 is required for its ability to activate protein kinase C
[LiteratureReference:2682231] Solution structure of a syndecan-4 cytoplasmic domain and its interaction with phosphatidylinositol 4,5-bisphosphate
[LiteratureReference:2684505] Syndecan-4 regulates localization, activity and stability of protein kinase C-alpha
modified[InstanceEdit:2867920] Jupe, S, 2012-12-19
[InstanceEdit:3597657] Jupe, S, 2013-05-22
textSyndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005).

Syndecans are also signalling molecules, interacting with cytoplasmic proteins. Most of the work done has involved syndecan-4 (Multhaupt et al. 2009). Zebrafish and murine syndecan-4 V regions bind the membrane lipid phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) undergoing a shape change revealed by NMR spectroscopy (Oh et al. 1998, Whiteford et al. 2008). The resulting complex is able to bind protein kinase C alpha which is persistently activated in the absence of Ca2+ (Oh et al. 1997, Lee et al. 1998, Keum et al. 2004).
(summation)[Reaction:2750187] Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG [Homo sapiens]
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