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Details on Person Syndecans have attached heparan sulfate (HS) and to a lesser...

Class:IdSummation:2731092
_displayNameSyndecans have attached heparan sulfate (HS) and to a lesser...
_timestamp2013-05-22 14:39:45
created[InstanceEdit:2731117] Jupe, S, 2012-12-05
literatureReference[LiteratureReference:2682240] Syndecans: new kids on the signaling block
[LiteratureReference:2684478] The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells
[LiteratureReference:2684471] Syndecan-1 regulates alphavbeta5 integrin activity in B82L fibroblasts
[LiteratureReference:2682229] Syndecans in wound healing, inflammation and vascular biology
[LiteratureReference:2682228] Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4
[LiteratureReference:2682312] Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice
[LiteratureReference:2682286] Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature
modified[InstanceEdit:2867920] Jupe, S, 2012-12-19
[InstanceEdit:3597657] Jupe, S, 2013-05-22
[InstanceEdit:3597706] Jupe, S, 2013-05-22
textSyndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005). It is thought that syndecans often act in concert with other receptors, e.g. alphavbeta3 and alphavbeta5 integrins cooperate with syndecan-1 during adhesion to vitronectin (Beauvais et al. 2004, McQuade et al. 2006). The relationship between syndecans and co-receptors is not well understood (Alexopoulou et al. 2007). Syndecan-null mice have subtle phenotypes when compared with mice deficient in HS chain synthesis or modification (Echtermeyer et al. 2001, Ishiquro et al. 2001, Götte et al. 2002).
(summation)[Reaction:2731085] Syndecan-1 binds integrin alphaVbeta3 [Homo sapiens]
[Reaction:2731123] Syndecan-1 binds Integrin alphaVbeta3 [Homo sapiens]
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