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Details on Person Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)

Class:Id	Reaction:2731074
_displayName	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)
_doRelease	TRUE
_timestamp	2013-07-04 14:29:31
authored	[InstanceEdit:2426268] Jupe, S, 2012-07-31
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2731117] Jupe, S, 2012-12-05
edited	[InstanceEdit:3318356] Jupe, S, 2013-04-26
input	[DefinedSet:2684506] Syndecan-1 [plasma membrane] [Homo sapiens] [CandidateSet:2731104] Integrin alpha2beta1, (alpha6beta4) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2684483] Laminin alpha1 chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin alpha2beta1 [LiteratureReference:2684503] The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain [LiteratureReference:2684478] The syndecan-1 ectodomain regulates alphavbeta3 integrin activity in human mammary carcinoma cells
modified	[InstanceEdit:2752107] Jupe, S, 2012-12-07 [InstanceEdit:2796108] Jupe, S, 2012-12-11 [InstanceEdit:3446769] Jupe, S, 2013-05-15 [InstanceEdit:3597657] Jupe, S, 2013-05-22 [InstanceEdit:3597687] Jupe, S, 2013-05-22 [InstanceEdit:3632860] Jupe, S, 2013-05-27 [InstanceEdit:3787960] Jupe, S, 2013-07-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)
output	[Complex:2731084] Syndecan-1:Integrin alpha2beta1 (alpha6beta4) [plasma membrane] [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3597658] Fuentes, Ernesto, 2013-05-22 [InstanceEdit:3597676] Ricard-Blum, Sylvie, 2013-05-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654235] R-HSA-2731074.2
summation	[Summation:2731105] Syndecans have attached heparan sulfate (HS) and to a lesser...
(hasEvent)	[Pathway:3000170] Syndecan interactions [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786978] Update Tracker - [Reaction:2731074] Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) - v46:[addLiteratureReference, modifyText]
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