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Details on Person Syndecans have attached heparan sulfate (HS) and to a lesser...

Class:Id	Summation:2731071
_displayName	Syndecans have attached heparan sulfate (HS) and to a lesser...
_timestamp	2013-07-04 14:29:37
created	[InstanceEdit:2731117] Jupe, S, 2012-12-05
literatureReference	[LiteratureReference:2682306] Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4 [LiteratureReference:2681684] Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region [LiteratureReference:2682218] Function of the syndecan-4 cytoplasmic domain in oligomerization and association with ?-actinin in turkey muscle satellite cells [LiteratureReference:2682229] Syndecans in wound healing, inflammation and vascular biology [LiteratureReference:2682240] Syndecans: new kids on the signaling block [LiteratureReference:2684465] Cell surface proteoglycan binds mouse mammary epithelial cells to fibronectin and behaves as a receptor for interstitial matrix [LiteratureReference:2682249] Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts [LiteratureReference:2731109] Control of extracellular matrix assembly by syndecan-2 proteoglycan [LiteratureReference:3788042] Syndecan-1 regulates cell migration and fibronectin fibril assembly
modified	[InstanceEdit:2867920] Jupe, S, 2012-12-19 [InstanceEdit:3597657] Jupe, S, 2013-05-22 [InstanceEdit:3787960] Jupe, S, 2013-07-04
text	Syndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins. Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005). Syndecans binds with extracellular matrix proteins, including fibronectin (Human syndecan-1, Saunders & Bernfield 1988; rat syndecan-4 in Woods et al. 2000; rat syndecan-2 to bovine fibronectin in Klass & Woods 2000). Syndecan-1 functions to regulate integrin activity and fibronectin fibril assembly (Stepp et al. 2010).
(summation)	[Reaction:2731141] Syndecan-1 binds fibronectin [Homo sapiens]
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No pathways have been reviewed or authored by Syndecans have attached heparan sulfate (HS) and to a lesser... (2731071)