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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Fc epsilon receptor (FCERI) signaling

Class:IdPathwayDiagram:2730920
_displayNameDiagram of Fc epsilon receptor (FCERI) signaling
_timestamp2025-05-05 07:20:09
created[InstanceEdit:2730915] Garapati, P V, 2012-12-05
height1649
modified[InstanceEdit:2871845] Garapati, P V, 2012-12-21
[InstanceEdit:2892447] Garapati, P V, 2013-01-02
[InstanceEdit:2896900] Garapati, P V, 2013-01-03
[InstanceEdit:3448746] Garapati, P V, 2013-05-16
[InstanceEdit:4420227] Garapati, P V, 2013-08-30
[InstanceEdit:5691380] Rothfels, Karen, 2015-05-06
[InstanceEdit:5691388] Garapati, Phani Vijay, 2015-05-07
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8863080] Garapati, Phani Vijay, 2016-03-04
[InstanceEdit:8951566] Jupe, Steve, 2016-12-08
[InstanceEdit:9016829] Jassal, Bijay, 2017-08-16
[InstanceEdit:9725211] Stephan, Ralf, 2021-03-29
[InstanceEdit:9725670] Stephan, Ralf, 2021-03-31
[InstanceEdit:9947329] Stephan, Ralf, 2025-05-05
representedPathway[Pathway:2454202] Fc epsilon receptor (FCERI) signaling [Homo sapiens]
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231, 2712 229, 2737 231" position="2712 229" lineWidth="1.0"> <Inputs> <Input id="439" points="2667 218" /> <Input id="442" points="2669 256" /> </Inputs> <Outputs> <Output id="443" points="2770 254" /> <Output id="444" points="2761 214" /> </Outputs> <Catalysts> <Catalyst id="21" points="1273 142, 1408 5, 2712 4" /> </Catalysts> <Properties> <displayName>Phosphorylation of TEC kinases by p-SYK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="446" reactomeId="2730858" points="2892 232, 2923 232, 2953 233" position="2923 232" lineWidth="1.0"> <Inputs> <Input id="447" points="2880 267" /> <Input id="444" points="2861 214" /> </Inputs> <Outputs> <Output id="448" points="2995 209" /> <Output id="449" points="2987 271" /> </Outputs> <Catalysts> <Catalyst id="444" points="2875 170, 2924 169" /> </Catalysts> <Properties> <displayName>Autophosphorylation of BTK/ITK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="450" reactomeId="2730888" points="3162 245, 3195 244, 3229 245" position="3195 244" lineWidth="1.0"> <Inputs> <Input id="448" points="3127 223" /> <Input id="451" stoichiometry="4" points="3147 283" /> </Inputs> <Outputs> <Output id="452" points="3262 222" /> <Output id="453" stoichiometry="4" points="3253 291" /> </Outputs> <Catalysts> <Catalyst id="454" points="3195 126" /> </Catalysts> <Properties> <displayName>Phosphorylation of PLC-gamma</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="455" points="1318 160, 2205 25, 3143 104" position="2205 25" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="454" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="456" points="3137 144, 3177 126" position="3157 135" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="448" /> </Inputs> <Outputs> <Output id="454" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="462" reactomeId="2730847" points="3559 216, 3519 216, 3471 216" position="3519 216" lineWidth="1.0"> <Inputs> <Input id="463" points="3572 238" /> <Input id="464" points="3578 183" /> </Inputs> <Outputs> <Output id="465" points="3458 241" /> <Output id="466" points="3445 186" /> </Outputs> <Catalysts> <Catalyst id="452" points="3386 143, 3522 78" /> </Catalysts> <Properties> <displayName>Hydrolysis of PIP2 by PLCG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="467" reactomeId="169680" points="3391 431, 3333 589, 3287 589" position="3333 589" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1826" points="3430 568" /> <Input id="465" stoichiometry="4" points="3448 273" /> </Inputs> <Outputs> <Output id="469" /> </Outputs> <Catalysts> <Catalyst id="1826" points="3395 589" /> </Catalysts> <Properties> <displayName>IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="474" reactomeId="74448" points="2877 661, 2876 661, 2838 661" position="2876 661" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="472" stoichiometry="4" points="2988 661" /> <Input id="1819" points="2938 631" /> </Inputs> <Outputs> <Output id="476" /> </Outputs> <Properties> <displayName>Calcium binds calmodulin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="482" reactomeId="2730872" points="2686 663, 2650 663, 2611 663" position="2650 663" lineWidth="1.0"> <Inputs> <Input id="472" stoichiometry="4" points="2988 667, 2785 710" /> <Input id="476" points="2718 663" /> <Input id="483" points="2740 638" /> </Inputs> <Outputs> <Output id="484" /> </Outputs> <Properties> <displayName>Activation of Calcineurin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="486" reactomeId="2730849" points="2460 665, 2432 665, 2400 665" position="2432 665" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="487" points="2499 707" /> <Input id="488" points="2484 743" /> <Input id="484" points="2482 665" /> </Inputs> <Outputs> <Output id="489" points="2356 665" /> <Output id="490" stoichiometry="13" points="2359 627" /> </Outputs> <Catalysts> <Catalyst id="484" points="2546 638, 2546 606, 2431 606" /> </Catalysts> <Properties> <displayName>Calcineurin binds and dephosphorylates NFAT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="491" reactomeId="2730867" points="2300 681, 2300 731, 2463 866" position="2300 731" lineWidth="1.0"> <Inputs> <Input id="489" /> </Inputs> <Outputs> <Output id="492" /> </Outputs> <Properties> <displayName>Translocation of CaN:CaM:NFAT to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="497" reactomeId="2730871" points="3768 133, 3870 132, 3907 149" position="3870 132" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="498" points="3751 219" /> <Input id="500" points="3681 220" /> <Input id="507" points="3792 154" /> </Inputs> <Outputs> <Output id="499" /> </Outputs> <Properties> <displayName>RasGRP interacts with DAG and Ca2+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="508" reactomeId="2730882" points="3947 284, 3947 315, 3947 349" position="3947 315" lineWidth="1.0"> <Inputs> <Input id="509" points="3928 274" /> <Input id="506" points="3962 245" /> </Inputs> <Outputs> <Output id="510" points="3903 370" /> <Output id="511" points="3965 380" /> </Outputs> <Catalysts> <Catalyst id="12" points="801 139, 914 27, 2416 18, 4045 12, 4046 313" /> </Catalysts> <Properties> <displayName>Phosphorylation of PKC-theta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="517" reactomeId="2730835" points="3905 436, 3907 456, 3909 477" position="3907 456" lineWidth="1.0"> <Inputs> <Input id="518" stoichiometry="4" points="3852 428" /> <Input id="511" points="3938 423" /> </Inputs> <Outputs> <Output id="519" stoichiometry="4" points="3866 491" /> <Output id="520" points="3933 483" /> </Outputs> <Properties> <displayName>Autophosphorylation of PKC-theta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="521" reactomeId="2730863" points="3912 561, 3910 587, 3912 609" position="3910 587" lineWidth="1.0"> <Inputs> <Input id="520" points="3962 524" /> <Input id="522" stoichiometry="2" points="3859 557" /> <Input id="523" points="3946 554" /> </Inputs> <Outputs> <Output id="524" stoichiometry="2" points="3861 622" /> <Output id="525" points="3928 616" /> </Outputs> <Catalysts> <Catalyst id="520" points="4009 524, 4099 585" /> </Catalysts> <Properties> <displayName>Phosphorylation of CARMA1 by PKC-theta</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="527" reactomeId="2730902" points="3890 676, 3890 705, 3919 706" position="3890 705" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="528" points="3851 672" /> <Input id="525" points="3928 662" /> </Inputs> <Outputs> <Output id="529" /> </Outputs> <Properties> <displayName>Oligomerization of p-CARMA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="530" reactomeId="2730836" points="3862 745, 3863 776, 3916 778" position="3863 776" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="529" points="3919 728" /> <Input id="531" points="3826 739" /> </Inputs> <Outputs> <Output id="532" /> </Outputs> <Properties> <displayName>Interaction of BCL10:MALT1 with CARMA1 to form CBM complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="535" reactomeId="2730899" points="3977 838, 3978 868, 3978 900" position="3978 868" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="536" points="3834 838" /> <Input id="537" points="3916 825" /> <Input id="532" points="3981 803" /> </Inputs> <Outputs> <Output id="538" /> </Outputs> <Properties> <displayName>Oligomerization of BCL10 and MALT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="539" reactomeId="2730864" points="3909 966, 3909 1002, 3932 1002" position="3909 1002" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="538" points="3950 942" /> <Input id="540" points="3873 937" /> </Inputs> <Outputs> <Output id="541" /> </Outputs> <Properties> <displayName>Recruitment of TRAF6 to CBM complex by binding to MALT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="544" reactomeId="2730903" points="3864 1081, 3864 1113, 3911 1113" position="3864 1113" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="541" points="3969 1027" /> <Input id="540" points="3863 937" /> </Inputs> <Outputs> <Output id="545" /> </Outputs> <Properties> <displayName>Oligomerization of TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="546" reactomeId="2730904" points="3915 1166, 3918 1209, 3917 1236" position="3918 1209" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="547" points="3836 1132" /> <Input id="548" points="3800 1208" /> <Input id="545" points="3950 1142" /> <Input id="549" points="3819 1165" /> </Inputs> <Outputs> <Output id="550" points="3882 1272" /> <Output id="548" points="3823 1228" /> <Output id="551" points="3939 1247" /> <Output id="552" points="3842 1262" /> </Outputs> <Catalysts> <Catalyst id="545" points="3976 1142, 3964 1210" /> </Catalysts> <Properties> <displayName>Auto-ubiquitination of TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="554" reactomeId="2730861" points="3870 1332, 3871 1365, 3905 1365" position="3871 1365" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="555" points="3796 1324" /> <Input id="551" points="3932 1304" /> </Inputs> <Outputs> <Output id="556" /> </Outputs> <Properties> <displayName>Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="559" reactomeId="2730900" points="3880 1434, 3879 1466, 3880 1502" position="3879 1466" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="560" stoichiometry="2" points="3854 1421" /> <Input id="556" points="3934 1404" /> </Inputs> <Outputs> <Output id="561" stoichiometry="2" points="3842 1494" /> <Output id="562" points="3912 1509" /> </Outputs> <Catalysts> <Catalyst id="556" points="3962 1404, 3916 1464" /> </Catalysts> <Properties> <displayName>Activation of TAK1 complex bound to pUb-TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="564" reactomeId="2730876" points="3554 1360, 3554 1331, 3554 1293" position="3554 1331" lineWidth="1.0"> <Inputs> <Input id="565" stoichiometry="2" points="3592 1405" /> <Input id="566" points="3526 1400" /> </Inputs> <Outputs> <Output id="567" stoichiometry="2" points="3514 1253" /> <Output id="568" points="3600 1242" /> </Outputs> <Catalysts> <Catalyst id="562" points="3912 1527, 3747 1530, 3641 1331" /> </Catalysts> <Properties> <displayName>Phosphorylation of IKK-beta by TAK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="577" reactomeId="202541" points="3623 921, 3577 921, 3547 921" position="3577 921" lineWidth="1.0"> <Inputs> <Input id="578" stoichiometry="2" points="3644 881" /> <Input id="579" points="3648 921" /> </Inputs> <Outputs> <Output id="1377" points="3508 921" /> <Output id="1378" stoichiometry="2" points="3517 869" /> </Outputs> <Catalysts> <Catalyst id="571" points="3551 1023" /> </Catalysts> <Properties> <displayName>p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="583" reactomeId="2730894" points="3020 795, 2948 842, 2888 883" position="2948 842" lineWidth="1.0"> <Inputs> <Input id="582" /> </Inputs> <Outputs> <Output id="584" /> </Outputs> <Properties> <displayName>NFKB1:RELA translocates from the cytosol to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="586" reactomeId="2730841" points="2412 1549, 2380 1550, 2358 1549" position="2380 1550" lineWidth="1.0"> <Inputs> <Input id="434" points="2345 211" /> <Input id="1818" points="2430 1527" /> </Inputs> <Outputs> <Output id="589" points="2307 1571" /> <Output id="588" points="2311 1527" /> </Outputs> <Activators> <Activator id="595" points="2378 1579" /> </Activators> <Properties> <displayName>Phosphorylation and activation of VAV</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="596" reactomeId="2730840" points="2165 1519, 2126 1520, 2086 1519" position="2126 1520" lineWidth="1.0"> <Inputs> <Input id="589" points="2211 1571" /> <Input id="597" points="2228 1481" /> <Input id="600" points="2184 1427" /> </Inputs> <Outputs> <Output id="598" points="2036 1563" /> <Output id="603" points="2037 1500" /> </Outputs> <Catalysts> <Catalyst id="589" points="2196 1571" /> </Catalysts> <Properties> <displayName>Activation of RAC1 by VAV</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="605" reactomeId="2730889" points="1882 1561, 1844 1561, 1807 1575" position="1844 1561" lineWidth="1.0"> <Inputs> <Input id="606" points="1928 1512" /> <Input id="598" points="1916 1572" /> </Inputs> <Outputs> <Output id="607" /> </Outputs> <Properties> <displayName>Recruitment of PAK to the membrane by binding active RAC1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="609" reactomeId="2730856" points="1723 1543, 1723 1499, 1722 1477" position="1723 1499" lineWidth="1.0"> <Inputs> <Input id="610" stoichiometry="4" points="1549 1545" /> <Input id="607" points="1723 1563" /> </Inputs> <Outputs> <Output id="598" points="1926 1563" /> <Output id="1379" stoichiometry="4" points="1671 1447" /> <Output id="1380" stoichiometry="2" points="1823 1433" /> </Outputs> <Catalysts> <Catalyst id="607" points="1640 1600, 1610 1600, 1610 1498" /> </Catalysts> <Properties> <displayName>Autophosphorylation of PAK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="613" reactomeId="2730887" points="1457 743, 1505 743, 1540 743" position="1505 743" lineWidth="1.0"> <Inputs> <Input id="614" points="1422 779" /> <Input id="615" stoichiometry="2" points="1426 726" /> </Inputs> <Outputs> <Output id="616" stoichiometry="2" points="1560 783" /> <Output id="617" points="1573 716" /> </Outputs> <Catalysts> <Catalyst id="614" points="1451 792, 1505 792" /> </Catalysts> <Activators> <Activator id="1380" points="1859 1395" /> </Activators> <Properties> <displayName>Autophosphorylation and activation of MEKK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="618" reactomeId="2730896" points="1817 728, 1855 728, 1890 728" position="1855 728" lineWidth="1.0"> <Inputs> <Input id="619" stoichiometry="2" points="1792 749" /> <Input id="620" points="1788 719" /> </Inputs> <Outputs> <Output id="621" stoichiometry="2" points="1928 748" /> <Output id="622" points="1924 714" /> </Outputs> <Catalysts> <Catalyst id="617" points="1593 674, 1593 625, 1855 655" /> </Catalysts> <Properties> <displayName>Phosphorylation of MEK4 by MEKK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="624" reactomeId="2730868" points="1829 803, 1861 803, 1897 803" position="1861 803" lineWidth="1.0"> <Inputs> <Input id="625" points="1801 825" /> <Input id="619" stoichiometry="2" points="1797 783" /> </Inputs> <Outputs> <Output id="628" points="1942 819" /> <Output id="621" stoichiometry="2" points="1935 779" /> </Outputs> <Catalysts> <Catalyst id="617" points="1594 716, 1594 809, 1861 890" /> </Catalysts> <Properties> <displayName>Phosphorylation of MEK7 by MEKK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="636" reactomeId="450348" points="2145 983, 2266 983, 2405 981" position="2266 983" lineWidth="1.0"> <Inputs> <Input id="633" /> </Inputs> <Outputs> <Output id="637" /> </Outputs> <Properties> <displayName>Activated human JNKs migrate to nucleoplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="638" reactomeId="2730884" points="156 450, 156 489, 158 522" position="156 489" lineWidth="1.0"> <Inputs> <Input id="639" stoichiometry="10" points="182 421" /> <Input id="640" points="126 418" /> </Inputs> <Outputs> <Output id="641" stoichiometry="10" points="193 547" /> <Output id="642" points="122 558" /> </Outputs> <Catalysts> <Catalyst id="21" points="1235 198, 1180 293" /> </Catalysts> <Properties> <displayName>Phosphorylation of NTAL by p-SYK/Lyn</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="679" reactomeId="2730837" points="364 648, 226 655, 181 658" position="226 655" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="642" points="160 594" /> <Input id="271" points="1372 495" /> </Inputs> <Outputs> <Output id="680" /> </Outputs> <Properties> <displayName>Recruitment of GRB2:SOS to p-10Y-NTAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="683" reactomeId="2730848" points="204 702, 166 737, 143 757" position="166 737" lineWidth="1.0"> <Inputs> <Input id="680" points="154 684" /> <Input id="684" points="277 695" /> <Input id="687" points="153 708" /> </Inputs> <Outputs> <Output id="685" /> </Outputs> <Properties> <displayName>Recruitment of GAB2 to PM and FCERI by binding to GRB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="690" reactomeId="2730860" points="195 838, 131 855, 192 871" position="131 855" lineWidth="1.0"> <Inputs> <Input id="685" points="155 813" /> <Input id="691" stoichiometry="3" points="226 809" /> </Inputs> <Outputs> <Output id="692" stoichiometry="3" points="238 887" /> <Output id="693" points="156 892" /> </Outputs> <Catalysts> <Catalyst id="694" points="98 863" /> </Catalysts> <Properties> <displayName>Phosphorylation of GAB2 by SYK/FYN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="695" points="1207 198, 81 853" position="644 525" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="694" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="696" points="98 862, 3143 119" position="1620 490" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="694" /> </Inputs> <Outputs> <Output id="454" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="699" reactomeId="2730842" points="119 962, 119 986, 119 1014" position="119 986" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="700" points="234 949, 190 957" /> <Input id="693" points="119 948" /> </Inputs> <Outputs> <Output id="701" /> </Outputs> <Properties> <displayName>PI3K associates with phosphorylated GAB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="702" reactomeId="2730870" points="118 1143, 118 1177, 118 1211" position="118 1177" lineWidth="1.0"> <Inputs> <Input id="703" points="191 1108" /> <Input id="708" points="105 1140" /> </Inputs> <Outputs> <Output id="704" points="192 1242" /> <Output id="706" points="91 1239" /> </Outputs> <Catalysts> <Catalyst id="701" points="57 1041, 8 1041, 41 1177" /> </Catalysts> <Properties> <displayName>Phosphorylation of PIP2 to PIP3 by PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="725" reactomeId="202164" points="126 1361, 126 1392, 126 1427" position="126 1392" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="726" points="217 1341" /> <Input id="727" points="126 1344" /> </Inputs> <Outputs> <Output id="732" /> </Outputs> <Properties> <displayName>Translocation of PDK1 to Plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="731" points="90 1275, 114 1302" position="102 1288" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="706" /> </Inputs> <Outputs> <Output id="727" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="737" reactomeId="168162" points="1892 982, 1931 982, 1981 982" position="1931 982" lineWidth="1.0"> <Inputs> <Input id="738" points="1851 981" /> <Input id="739" stoichiometry="2" points="1871 1024" /> </Inputs> <Outputs> <Output id="633" points="2018 982" /> <Output id="740" stoichiometry="2" points="1997 1029" /> </Outputs> <Catalysts> <Catalyst id="741" points="1931 940" /> </Catalysts> <Properties> <displayName>Phosphorylation of human JNKs by activated MKK4/MKK7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="742" points="1971 721, 1935 892" position="1953 806" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="622" /> </Inputs> <Outputs> <Output id="741" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="743" points="1973 864, 1946 892" position="1959 878" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="628" /> </Inputs> <Outputs> <Output id="741" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="780" reactomeId="169683" points="3164 660, 3120 660, 3052 660" position="3120 660" lineWidth="1.0"> <Inputs> <Input id="781" /> </Inputs> <Outputs> <Output id="472" /> </Outputs> <Catalysts> <Catalyst id="469" points="3196 611, 3163 631" /> </Catalysts> <Inhibitors> <Inhibitor id="1381" points="3032 551" /> </Inhibitors> <Activators> <Activator id="465" points="3429 273, 3120 438" /> </Activators> <Properties> <displayName>IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1336" reactomeId="202534" points="3695 1130, 3652 1104, 3619 1088" position="3652 1104" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="568" points="3630 1201" /> <Input id="575" points="3631 1145" /> <Input id="549" points="3741 1151" /> </Inputs> <Outputs> <Output id="571" points="3577 1066" /> <Output id="575" points="3586 1136" /> </Outputs> <Catalysts> <Catalyst id="1337" points="3681 1070" /> </Catalysts> <Properties> <displayName>Ubiquitination of NEMO by TRAF6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1342" reactomeId="168136" points="2613 1056, 2641 1056, 2665 1056" position="2641 1056" lineWidth="1.0"> <Inputs> <Input id="1343" points="2593 1044" /> <Input id="1344" stoichiometry="2" points="2594 1075" /> </Inputs> <Outputs> <Output id="1345" stoichiometry="2" points="2692 1076" /> <Output id="1346" points="2688 1040" /> </Outputs> <Catalysts> <Catalyst id="637" points="2517 981, 2640 984" /> </Catalysts> <Properties> <displayName>Activated JNKs phosphorylate c-JUN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1361" reactomeId="450325" points="2615 1194, 2648 1194, 2682 1194" position="2648 1194" lineWidth="1.0"> <Inputs> <Input id="1362" stoichiometry="4" points="2600 1209" /> <Input id="1363" points="2600 1175" /> </Inputs> <Outputs> <Output id="1364" stoichiometry="4" points="2711 1219" /> <Output id="1365" points="2694 1175" /> </Outputs> <Catalysts> <Catalyst id="1368" points="2647 1241" /> </Catalysts> <Properties> <displayName>c-FOS activation by phospho ERK1/2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1366" reactomeId="450292" points="2773 1083, 2808 1083, 2852 1083" position="2808 1083" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1346" points="2725 1040" /> <Input id="1365" points="2728 1125" /> </Inputs> <Outputs> <Output id="1367" /> </Outputs> <Properties> <displayName>Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="1374" interactionType="Activate" points="181 1440, 417 1437" position="299 1438" lineWidth="2.0"> <Inputs> <Input id="732" /> </Inputs> <Outputs> <Output id="1371" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="1392" interactionType="Activate" points="1788 454, 1845 454" position="1816 454" lineWidth="2.0"> <Inputs> <Input id="284" /> </Inputs> <Outputs> <Output id="1390" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="1487" reactomeId="5607728" points="3341 920, 3306 920, 3272 920" position="3306 920" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1377" points="3363 920" /> <Input id="1488" points="3320 878" /> <Input id="1489" points="3314 970" /> <Input id="1490" stoichiometry="4" points="3392 980" /> </Inputs> <Outputs> <Output id="1488" points="3301 878" /> <Output id="1491" points="3250 920" /> <Output id="1489" points="3302 970" /> </Outputs> <Catalysts> <Catalyst id="1489" points="3308 970" /> </Catalysts> <Properties> <displayName>beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1508" reactomeId="5607724" points="3150 895, 3102 846, 3048 795" position="3102 846" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1491" /> </Inputs> <Outputs> <Output id="582" /> </Outputs> <Catalysts> <Catalyst id="1509" points="3161 784" /> </Catalysts> <Properties> <displayName>26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1779" reactomeId="202328" points="3850 222, 3877 222, 3907 222" position="3877 222" lineWidth="1.0"> <Inputs> <Input id="505" points="3809 286" /> <Input id="507" points="3817 186" /> </Inputs> <Outputs> <Output id="506" /> </Outputs> <Properties> <displayName>Translocation of PKC theta to plasma membrane</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1820" reactomeId="9725206" points="399 140, 444 140, 473 155" position="444 140" lineWidth="1.0"> <Inputs> <Input id="1821" points="331 107" /> <Input id="1822" points="377 154" /> </Inputs> <Outputs> <Output id="2" /> </Outputs> <Properties> <displayName>IgE binds FCERI</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1823" reactomeId="9724685" points="251 77, 251 77, 170 77" position="251 77" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1821" points="299 96" /> <Input id="1824" points="305 59" /> </Inputs> <Outputs> <Output id="1825" /> </Outputs> <Properties> <displayName>IgE binds omalizumab</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Fc epsilon receptor (FCERI) signaling (2730920)
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