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Details on Person Recruitment of VAV to p-SLP-76

Class:Id	Reaction:2730892
_displayName	Recruitment of VAV to p-SLP-76
_doRelease	TRUE
_timestamp	2013-05-31 09:38:51
authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
input	[DefinedSet:430172] VAV1,2,3 [cytosol] [Homo sapiens] [Complex:2424460] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:430166] Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation [LiteratureReference:2685200] Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway [LiteratureReference:2685370] Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells
modified	[InstanceEdit:2871845] Garapati, P V, 2012-12-21 [InstanceEdit:3139041] Garapati, P V, 2013-02-13 [InstanceEdit:3165217] Garapati, P V, 2013-02-22 [InstanceEdit:3448700] Garapati, P V, 2013-05-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of VAV to p-SLP-76
output	[Complex:2685668] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2730851] Phosphorylation of SLP-76 by p-SYK [Homo sapiens] [Reaction:2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654256] R-HSA-2730892.2
summation	[Summation:2685563] VAV an activator of RAC-GTPases, is redistributed to plasma ...
(hasEvent)	[Pathway:2871796] FCERI mediated MAPK activation [Homo sapiens]
(precedingEvent)	[Reaction:2730841] Phosphorylation and activation of VAV [Homo sapiens] [Reaction:2730885] Recruitment of TEC kinases to p-SLP-76 [Homo sapiens]
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No pathways have been reviewed or authored by Recruitment of VAV to p-SLP-76 (2730892)