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Details on Person Interaction of GRB2:SOS complex with p-SHC1

Class:Id	Reaction:2730844
_displayName	Interaction of GRB2:SOS complex with p-SHC1
_doRelease	TRUE
_timestamp	2013-05-31 09:43:32
authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
input	[EntityWithAccessionedSequence:1433505] p-Y239,Y240,Y317-SHC1-2 [cytosol] [Homo sapiens] [Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1169463] Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes [LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 [LiteratureReference:2685220] Adapters in the organization of mast cell signaling
modified	[InstanceEdit:2871845] Garapati, P V, 2012-12-21 [InstanceEdit:3139041] Garapati, P V, 2013-02-13 [InstanceEdit:3165217] Garapati, P V, 2013-02-22 [InstanceEdit:3448700] Garapati, P V, 2013-05-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Interaction of GRB2:SOS complex with p-SHC1
output	[Complex:2685672] p-SHC1:GRB2:SOS [cytosol] [Homo sapiens]
precedingEvent	[Reaction:2730886] Phosphorylation of SHC by SYK kinase [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654376] R-HSA-2730844.2
summation	[Summation:2685576] GRB2 is an adapter protein that contains a central SH2 domai...
(hasEvent)	[Pathway:2871796] FCERI mediated MAPK activation [Homo sapiens]
(precedingEvent)	[Reaction:2396599] Recruitment of GRB2:SOS to p-5Y-LAT [Homo sapiens] [Reaction:2730837] Recruitment of GRB2:SOS to p-10Y-NTAL [Homo sapiens]
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No pathways have been reviewed or authored by Interaction of GRB2:SOS complex with p-SHC1 (2730844)