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Details on Person Syndecans have attached heparan sulfate (HS) and to a lesser...

Class:IdSummation:2684513
_displayNameSyndecans have attached heparan sulfate (HS) and to a lesser...
_timestamp2013-05-22 14:39:43
created[InstanceEdit:2684510] Jupe, S, 2012-11-30
literatureReference[LiteratureReference:2682306] Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4
[LiteratureReference:2681684] Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region
[LiteratureReference:2682218] Function of the syndecan-4 cytoplasmic domain in oligomerization and association with ?-actinin in turkey muscle satellite cells
[LiteratureReference:2682229] Syndecans in wound healing, inflammation and vascular biology
[LiteratureReference:2684466] Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor
[LiteratureReference:2684492] Possible regulation of FGF activity by syndecan, an integral membrane heparan sulfate proteoglycan
[LiteratureReference:2682290] Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican
[LiteratureReference:3597709] Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2
[LiteratureReference:2682240] Syndecans: new kids on the signaling block
modified[InstanceEdit:2867920] Jupe, S, 2012-12-19
[InstanceEdit:3597657] Jupe, S, 2013-05-22
[InstanceEdit:3597706] Jupe, S, 2013-05-22
textSyndecans have attached heparan sulfate (HS) and to a lesser extent chondroitin sulfate (CS) chains. These allow interactions with a large number of proteins, including heparin-binding growth factors such as fibroblast growth factors (FGFs), mediating interaction with FGF receptors (Kiefer et al. 1990, Bernfield & Hooper 1991, Steinfeld et al. 1996, Chua et al. 2004). Various enzymes involved in post-translational HS chain modifications produce unique binding motifs that selectively recognize different proteins (Tkachenko et al. 2005).
(summation)[Reaction:2684507] Syndecans 1, 2, 4, (3) bind FGF2 [Homo sapiens]
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