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Details on Person Phosphorylated Lepr Binds Socs3

Class:Id	Reaction:2672295
_displayName	Phosphorylated Lepr Binds Socs3
_doRelease	TRUE
_timestamp	2013-10-26 10:15:28
authored	[InstanceEdit:2672229] May, B, 2012-11-27
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2672306] May, B, 2012-11-27
edited	[InstanceEdit:2672229] May, B, 2012-11-27
input	[Complex:2586540] Lep:p-Lepr:p-Jak2 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:1169197] Socs3 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:1169197] Socs3 [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2672304] SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985 [LiteratureReference:2672299] SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities [LiteratureReference:2672297] Mechanism of attenuation of leptin signaling under chronic ligand stimulation
modified	[InstanceEdit:3110010] May, B, 2013-02-10 [InstanceEdit:3165219] May, B, 2013-02-22 [InstanceEdit:4420241] May, B, 2013-08-31 [InstanceEdit:4789069] May, B, 2013-10-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated Lepr Binds Socs3
output	[Complex:2672300] Lep:p-Lepr:p-Jak2:Socs3 [plasma membrane] [Mus musculus]
precedingEvent	[Reaction:2586557] Jak2 Phosphorylates Lepr [Mus musculus] [Reaction:2586548] Jak2 Autophosphorylates in Response to Leptin [Mus musculus]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:4545167] R-MMU-2672295.2
summation	[Summation:2672303] Socs3 binds phosphotyrosine-985 (Bjorbaek et al. 2000, De So...
(inferredFrom)	[Reaction:2672302] Phosphorylated LEPR Binds SOCS3 [Homo sapiens]
(replacementInstances)	[_Deleted:9032439] Deletion of instance: 2586551 [_Deleted:9032440] Deletion of instance: 5334727
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No pathways have been reviewed or authored by Phosphorylated Lepr Binds Socs3 (2672295)