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Details on Person Viral serpin blocks caspase-8 activity

Class:Id	Reaction:2672196
_displayName	Viral serpin blocks caspase-8 activity
_doRelease	TRUE
_timestamp	2020-08-30 11:58:10
authored	[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2672226] Shamovsky, V, 2012-11-27
disease	[Disease:3134794] viral infectious disease
edited	[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
goBiologicalProcess	[GO_BiologicalProcess:260884] symbiont-mediated suppression of host apoptosis
input	[Complex:2562550] active caspase-8 [cytosol] [Homo sapiens] [DefinedSet:2672224] viral serpins [cytosol] [Cowpox virus]
isChimeric	FALSE
literatureReference	[LiteratureReference:2672185] Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product [LiteratureReference:2672213] Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever [LiteratureReference:2672173] Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway [LiteratureReference:2672165] Target protease specificity of the viral serpin CrmA. Analysis of five caspases
modified	[InstanceEdit:3465520] Shamovsky, V, 2013-05-17 [InstanceEdit:3508822] Shamovsky, V, 2013-05-17 [InstanceEdit:5364251] Shamovsky, V, 2014-04-21 [InstanceEdit:5626942] Shamovsky, V, 2014-10-14 [InstanceEdit:5627593] Shamovsky, V, 2014-10-20 [InstanceEdit:5632358] Jassal, Bijay, 2014-10-28 [InstanceEdit:5643754] Shamovsky, Veronica, 2014-11-17 [InstanceEdit:5667068] Shamovsky, V, 2015-01-23 [InstanceEdit:5675043] Shamovsky, V, 2015-02-15 [InstanceEdit:5678349] Shamovsky, V, 2015-02-23 [InstanceEdit:5686176] Shamovsky, Veronica, 2015-03-31 [InstanceEdit:5692576] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25 [InstanceEdit:9692667] Shamovsky, Veronica, 2020-06-25 [InstanceEdit:9698855] Shamovsky, Veronica, 2020-08-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9910117] Weiser, Joel, 2024-05-14
name	Viral serpin blocks caspase-8 activity
output	[Complex:2672221] active caspase-8:viral CRMA/SPI-2 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:139952] Caspase-8 processing in the DISC [Homo sapiens] [Reaction:141156] TRAIL-mediated dimerization of procaspase-8 [Homo sapiens] [Reaction:141159] TNF-mediated dimerization of procaspase-8 [Homo sapiens] [Reaction:73945] FAS-mediated dimerization of procaspase-8 [Homo sapiens]
relatedSpecies	[Species:2671792] Cowpox virus [Species:2671785] Vaccinia virus
releaseDate	2015-03-19
reviewed	[InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:6792551] Wajant, Harald, 2015-08-25 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5695682] R-HSA-2672196.5
summation	[Summation:2672191] SPI-2/CrmA (cytokine response modifier A) is a poxvirus gene...
systematicName	Viral serpins bind active caspase-8
(hasEvent)	[Pathway:5357905] Regulation of TNFR1 signaling [Homo sapiens] [Pathway:9686347] Microbial modulation of RIPK1-mediated regulated necrosis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776777] Update Tracker - [Reaction:2672196] Viral serpin blocks caspase-8 activity - v74:[modifyText] [_UpdateTracker:9784782] Update Tracker - [Reaction:2672196] Viral serpin blocks caspase-8 activity - v53:[modifyText]
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